Daucus Carota oil extract, a chemotherapeutic agent, acts as an antidepressant that promotes resilience to chronic social defeat stress

LAUR Repository

Show simple item record

dc.contributor.author Houbeika, Rouba
dc.date.accessioned 2022-06-16T08:09:49Z
dc.date.available 2022-06-16T08:09:49Z
dc.date.copyright 2021 en_US
dc.date.issued 2021-07-23
dc.identifier.uri http://hdl.handle.net/10725/13707
dc.description.abstract Cancer is second leading cause of death worldwide affecting more than 15 million individuals. Many risk factors play an important role in the development of cancer. These alterations give rise to cancerous cells with an ability to grow, divide and proliferate indefinitely. Multiple pathways are involved in cancer propagation. The survival and spreading of cancerous cells are regulated by the MAPK/ERK and PI3K/AKT pathways. Major depressive disorder is a mental illness diagnosed in many cancer patients. It is characterized by a decrease in hippocampal size and disruption of normal synaptic plasticity. A decrease in the hippocampal p-Akt protein levels is observed in depressed subjects. In addition, the MAPK/ERK pathway has been extensively studied and targeted for therapies. In addition, a decrease in the hippocampal brain derived neurotrophic factor (BDNF) protein level has been reported in postmortem human brains of depressed patients. Daucus carota L. ssp. Carota commonly known as the wild carrot is grown in Lebanon. It is used as folk medicine to treat many diseases such as diabetes mellitusand cancer. β-2-himachalen-6-ol (HC-6-ol), its major compound, causes a dose-dependent decrease in cell viability, induces cell cycle arrest, and promotes apoptosis in cancer cells. In this study, we used the chronic social defeat stress model to induce depressive-like behaviors in mice and studied the effect of the Daucus carota oil extract (DCOE) and HC-6-ol on social behavior following chronic stress. Our work revealed that DCOE promoted resilience to chronic stress independent from its major active component HC-6-ol. In contrast, when used as therapies to rescue depressive-like behaviors, both the DCOE and β-2-himachalen-6-ol were equally efficient. Our results suggest that different components of DCOE are responsible for its preventative effects as compared its therapeutic effects. Finally, our results could possibly implicate the hippocampal AKT pathway in the therapeutic effect of DCOE and HC-6-ol. en_US
dc.language.iso en en_US
dc.subject Carrots -- Therapeutic use en_US
dc.subject Cancer cells -- Proliferation en_US
dc.subject Metastasis -- Prevention en_US
dc.subject Patients -- Psychology en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title Daucus Carota oil extract, a chemotherapeutic agent, acts as an antidepressant that promotes resilience to chronic social defeat stress en_US
dc.type Thesis en_US
dc.term.submitted Summer en_US
dc.author.degree Doctor of Pharmacy en_US
dc.author.school SAS en_US
dc.author.idnumber 201504957 en_US
dc.author.commembers Khalil, Christian
dc.author.commembers Daher, Costantine
dc.author.department Natural Sciences en_US
dc.description.physdesc 1 online resource (x, 42 leaves): ill. (some col.) en_US
dc.author.advisor Sleiman, Sama
dc.keywords Cancer en_US
dc.keywords depression en_US
dc.keywords Daucus Carota en_US
dc.keywords β-2-himachalen-6-ol en_US
dc.keywords chronic social defeat stress en_US
dc.keywords PI3K/AKT pathway en_US
dc.keywords MAPK/ERK pathway en_US
dc.keywords BDNF en_US
dc.description.bibliographiccitations Includes bibliographical references (leaf 36-42) en_US
dc.identifier.doi  https://doi.org/10.26756/th.2022.207
dc.author.email rouba.houbeika@lau.edu en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search LAUR

Advanced Search


My Account