Palladin is a Positive Regulator of Astrocytoma Cell Migration

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dc.contributor.author Jabbour, Caren
dc.date.accessioned 2022-06-13T10:49:55Z
dc.date.available 2022-06-13T10:49:55Z
dc.date.copyright 2021 en_US
dc.date.issued 2021-07-30
dc.identifier.uri http://hdl.handle.net/10725/13641
dc.description.abstract Astrocytomas are characterized by uncontrolled proliferation and high invasion to adjacent normal regions of the brain. They originate from the normal glial cells, astrocytes. Astrocytomas are also referred to as glioblastoma, a rapidly dividing glioma. The invasion of astrocytomas to nearby sites requires cell migration which has been shown to be highly dependent on the small family of Rho GTPases. Cell motility has been extensively studied and several signaling pathways are involved in the process. In our study, we focused on the newly discovered phosphoprotein Palladin. It has been shown that it is implicated in the cell migration, invasion and adhesion of many other types of cancers as well as playing a role in the activation of Rho GTPases. Adequately, we were interested to unravel the role of palladin on the 2D cell migration of astrocytomas. In addition, we compared and tested the effect of palladin on two important Rho GTPases: Cdc42 and Rac1. The results of our investigation evidenced that palladin is a positive regulator of astrocytoma cell migration. en_US
dc.language.iso en en_US
dc.subject Astrocytomas en_US
dc.subject Rho GTPases en_US
dc.subject Brain -- Cancer -- Treatment en_US
dc.subject Cell division en_US
dc.title Palladin is a Positive Regulator of Astrocytoma Cell Migration en_US
dc.type Thesis en_US
dc.term.submitted Summer en_US
dc.author.degree Doctor of Pharmacy en_US
dc.author.school SAS en_US
dc.author.idnumber 201602202 en_US
dc.author.commembers Ghassibe-Sabbagh, Michella
dc.author.commembers Georgess, Dan
dc.author.department Natural Sciences en_US
dc.description.physdesc 1 online resource (xiv, 44 leaves) : ill. (some col.) en_US
dc.author.advisor El Sibai, Mirvat
dc.keywords Astrocytoma en_US
dc.keywords Palladin en_US
dc.keywords Cell migration en_US
dc.keywords Rho GTPases en_US
dc.keywords Cdc42 en_US
dc.keywords Rac1 en_US
dc.description.bibliographiccitations Includes bibliographical references (leaf 35-44) en_US
dc.identifier.doi https://doi.org/10.26756/th.2022.265
dc.author.email karen.jabbour01@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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