Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling

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dc.contributor.author Khalifeh, Mohamad Rabieh
dc.date.accessioned 2022-05-17T11:57:46Z
dc.date.available 2022-05-17T11:57:46Z
dc.date.copyright 2020 en_US
dc.date.issued 2020-03-18
dc.identifier.uri http://hdl.handle.net/10725/13574
dc.description.abstract The purpose of this study was to investigate how nicotine in the context of waterpipe tobacco smoking (WTS) affects depression and anxiety-like behaviors associated with chronic social defeat stress (CSDS) in a male C57BL/6J animal model. The mice were exposed to WTS or received intraperitoneal injections of nicotine for thirty days, before being subjected to CSDS for ten days. During CSDS, mice were exposed to WTS or received nicotine injections. The social interaction and open-field tests were used to classify animals as resilient or susceptible to stress and to evaluate their anxiety-like behavior and social interaction. Mice post behavioral testing, were further exposed to WTS/nicotine for ten days, and their behavior was reassessed. The involvement of brain-derived neurotrophic factor signaling in the nicotine-mediated effects was assessed with the tropomyosin receptor kinase B (TRKB) inhibitor, ANA-12. The reported results indicated that WTS promoted resilience to stress and rescued social avoidance in the used mice model. Even though initially, WTS decreased anxiety-like behaviors it was found that prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. Finally, we showed that nicotine mediates the effects of WTS only on resilience to stress by increasing BDNF and TRKB levels and signaling. Our results suggested that the pathways mediating resilience to stress and anxiety are distinct and that nicotine mediates the effects of WTS on social behavior, but not anxiety, by activating BDNF signaling. en_US
dc.language.iso en en_US
dc.subject Nicotine -- Physiological effect en_US
dc.subject Nicotine -- Psychological aspects en_US
dc.subject Smoking -- Psychological aspects en_US
dc.subject Neurotrophic functions en_US
dc.subject Stress (Psychology) -- Health aspects en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree Doctor of Pharmacy en_US
dc.author.school SAS en_US
dc.author.idnumber 201500840 en_US
dc.author.commembers Khnayzer, Rony
dc.author.commembers Khalil, Christian
dc.author.department N/A en_US
dc.description.physdesc 1 online (x, 82 leaves) ; ill. (some col.) en_US
dc.author.advisor Sleiman, Sama
dc.keywords Waterpipe Tobacco en_US
dc.keywords Nicotine en_US
dc.keywords Chronic Social Defeat Stress en_US
dc.keywords Depression en_US
dc.keywords BDNF en_US
dc.keywords Hippocampus en_US
dc.description.bibliographiccitations Includes bibliographical references (leaf 66-82) en_US
dc.identifier.doi https://doi.org/10.26756/th.2022.274
dc.author.email mohamadrabieh.khalifeh@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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