Autophagy Mediates the Effects of Physical Exercise on Learning and Memory through Activation of Hippocampal BDNF

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dc.contributor.author Jabr, Vanessa
dc.date.accessioned 2022-04-12T11:45:01Z
dc.date.available 2022-04-12T11:45:01Z
dc.date.copyright 2020 en_US
dc.date.issued 2020-07-30
dc.identifier.uri http://hdl.handle.net/10725/13485
dc.description.abstract Physical exercise is known to enhance learning and memory formation in the brain. These positive outcomes are mediated through the induction of the expression of a growth factor, brain derived neurotrophic factor (BDNF), in the hippocampus. BDNF promotes cognitive behaviors and induces brain plasticity. Previous work has also reported that stimulating autophagy can restore cognitive ability. In this study, we demonstrated that a short-term voluntary exercise paradigm is sufficient to upregulate autophagy in different brain regions in an age-dependent manner. This increase in autophagy was correlated with enhanced spatial learning and memory formation particularly in mature adult mice (10-week-old). Indeed, we showed that short-term voluntary wheel running increases the protein expression levels of the autophagy marker, protein light chain 3 (LC3B), in the hippocampus of 10-week-old mice. We used the Morris Water Maze to evaluate spatial learning and memory performance in mice belonging to different age groups. Our work revealed that 10-week-old exercising mice that were treated with a brain-permeable autophagy inhibitor during the behavioral test showed cognitive deficits in the maze suggesting that induction of autophagy is necessary for exercise-induced learning and memory formation. Interestingly, we also found that inhibition of autophagy in exercising 10-week-old mice decreases BDNF protein levels in the hippocampus as compared to the control exercising group. Overall, our results suggest that BDNF acts downstream of exercise-induced autophagy to promote learning and memory formation in mature adult mice. We found that this pathway is not conserved in juvenile or middle-aged mice. en_US
dc.language.iso en en_US
dc.subject Hippocampus (Brain) -- Physiology en_US
dc.subject Memory -- Physiological aspects en_US
dc.subject Learning -- Physiological aspects en_US
dc.subject Autophagic vacuoles -- Therapeutic use en_US
dc.subject Exercise -- Physiological aspects en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title Autophagy Mediates the Effects of Physical Exercise on Learning and Memory through Activation of Hippocampal BDNF en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree Doctor of Pharmacy en_US
dc.author.school SAS en_US
dc.author.idnumber 201407879 en_US
dc.author.commembers Stephan, Joseph
dc.author.commembers Tokajian, Sima
dc.author.department Natural Sciences en_US
dc.description.physdesc 1 online resource (ix, 45 leaves) : ill. (some col.) en_US
dc.author.advisor Sleiman, Sama
dc.keywords Voluntary exercise en_US
dc.keywords autophagy en_US
dc.keywords BDNF en_US
dc.keywords learning en_US
dc.keywords memory en_US
dc.keywords aging en_US
dc.description.bibliographiccitations Includes bibliographical references (leaf 35-45). en_US
dc.identifier.doi https://doi.org/10.26756/th.2022.302
dc.author.email vanessa.jabre@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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