A Prospective observational cohort of clinical outcomes in medical inpatients prescribed pharmacological thromboprophylaxis using different clinical risk assessment models (COMPT RAMs)

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dc.contributor.author Chamoun, Nibal
dc.contributor.author Matta, Stephanie
dc.contributor.author Aderian, Sandrine Sarine
dc.contributor.author Salibi, Rami
dc.contributor.author Salameh, Pascale
dc.contributor.author Tayeh, Gaby
dc.contributor.author Haddad, Elie
dc.contributor.author Ghanem, Hady
dc.date.accessioned 2022-03-11T13:01:34Z
dc.date.available 2022-03-11T13:01:34Z
dc.date.copyright 2019 en_US
dc.date.issued 2022-03-11
dc.identifier.issn 2045-2322 en_US
dc.identifier.uri http://hdl.handle.net/10725/13387
dc.description.abstract The Caprini and Padua venous thromboembolism (VTE) risk assessment models (RAMs) are used to assess VTE risk in surgical and in medical patients respectively. This study aims to compare the proportion of medical inpatients eligible for VTE prophylaxis using the hospital Caprini-based RAM to using the Caprini and Padua RAMs and to assess the associated clinical outcomes. In a prospective observational study, we assessed 297 adult medical inpatients for whom VTE thromboprophylaxis was initiated according to the hospital Caprini-based RAM, referred to as the Lebanese American University Medical Center RAM (LAUMC-RAM). The Padua, Caprini and IMPROVE bleeding risk scores were also assessed for all patients. Bleeding and thromboembolism were evaluated at 14 and 30 days post VTE risk assessment. Pharmacologic thromboprophylaxis was warranted in 97.6%, 99.7%, and 52.9% of patients using the Caprini-based, Caprini, and Padua RAMs respectively. The Caprini-based and Caprini RAMs were highly correlated (r = 0.873 p < 0.001) and were significantly less correlated with the Padua RAM. Major and overall bleeding occurred in 1.4% and 9.2% respectively. VTE was reported in 0.4% with no VTE related mortality. In hospitalized medical patients, the Caprini-based RAM can accurately distinguish low and high VTE risk without resulting in increased risk of bleeding. en_US
dc.language.iso en en_US
dc.title A Prospective observational cohort of clinical outcomes in medical inpatients prescribed pharmacological thromboprophylaxis using different clinical risk assessment models (COMPT RAMs) en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.school SOM
dc.author.idnumber 200201071 en_US
dc.author.idnumber 201306055 en_US
dc.author.department Pharmacy Practice en_US
dc.relation.journal Scientific Reports en_US
dc.journal.volume 9 en_US
dc.journal.issue 1 en_US
dc.article.pages 1-9 en_US
dc.keywords Health care en_US
dc.keywords Medical research en_US
dc.identifier.doi https://doi.org/10.1038/s41598-019-54842-3 en_US
dc.identifier.ctation Chamoun, N., Matta, S., Aderian, S. S., Salibi, R., Salameh, P., Tayeh, G., ... & Ghanem, H. (2019). A Prospective Observational Cohort of Clinical Outcomes in Medical Inpatients prescribed Pharmacological Thromboprophylaxis Using Different Clinical Risk Assessment Models (COMPT RAMs). Scientific reports, 9(1), 1-9. en_US
dc.author.email nibal.chamoun@lau.edu.lb en_US
dc.author.email hady.ghanem@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.nature.com/articles/s41598-019-54842-3 en_US
dc.orcid.id https://orcid.org/0000-0002-0987-296X en_US
dc.orcid.id https://orcid.org/ 0000-0002-3575-2187 en_US
dc.author.affiliation Lebanese American University en_US

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