Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition

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dc.contributor.author Bouclaous, Carmel
dc.contributor.author Torbay, Naji
dc.contributor.author Nassar, Camille
dc.contributor.author Baba, Nahla Hwalla
dc.date.accessioned 2020-06-29T09:03:49Z
dc.date.available 2020-06-29T09:03:49Z
dc.date.copyright 2003 en_US
dc.identifier.issn 1879-0739 en_US
dc.identifier.uri http://hdl.handle.net/10725/11936
dc.description.abstract The effects of macronutrient composition of the diet and glucocorticoid administration on weight gain, intestinal absorption and plasma lipids were investigated. Thirty seven male Wistar rats were divided into 4 groups, implanted with pellets continuously delivering either prednisolone (0.25mg/day) or placebo and fed two isocaloric diets providing either high fat (HF: 50% of energy) or high carbohydrate (HC: 70% of energy). The four groups [group I (HC, placebo), group II (HC, prednisolone), group III (HF, placebo), group IV (HF, prednisolone)] were pair fed and given the mean amount of food eaten by the group with the least amount of energy intake on the previous day. After 4 weeks, the animals were sacrificed and serum glucose, total cholesterol (TC), HDL-cholesterol (HDL) and triglycerides (TG) were measured. All groups showed a decrease in relative intestinal absorption with time. Prednisolone-treated groups revealed significantly lower intestinal absorption. However, prednisolone-treated high-carbohydrate (HC) fed rats showed significantly higher weight gain, concomitant with a significant increase in feed efficiency. The HC diet induced a statistically significant increase in TG concentration. The results show that prednisolone treatment induces more weight gain on a HC as compared to a high fat (HF) diet possibly through a rise in feed efficiency. en_US
dc.language.iso en en_US
dc.title Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber https://orcid.org/0000-0002-3832-0806 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Nutrition Research en_US
dc.journal.volume 23 en_US
dc.journal.issue 8 en_US
dc.article.pages 1105-1115 en_US
dc.keywords Glucocorticoids en_US
dc.keywords Pair feeding en_US
dc.keywords Weight gain en_US
dc.keywords Intestinal absorption en_US
dc.identifier.doi https://doi.org/10.1016/S0271-5317(03)00104-0 en_US
dc.identifier.ctation Bouclaous, C., Torbay, N., Nassar, C., & Hwalla, N. (2003). Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition. Nutrition Research, 23(8), 1105-1115. en_US
dc.author.email carmel.bouclaous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S0271531703001040 en_US
dc.orcid.id 201505343 en_US
dc.author.affiliation Lebanese American University en_US

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