Rho A and Rac1

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dc.contributor.author Salloum, Gilbert
dc.contributor.author Jaafar, Leila
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2020-05-01T14:18:10Z
dc.date.available 2020-05-01T14:18:10Z
dc.date.copyright 2020 en_US
dc.date.issued 2020-05-01
dc.identifier.issn 0040-8166 en_US
dc.identifier.uri http://hdl.handle.net/10725/11879
dc.description.abstract Cells detect external stimuli through cell-surface receptors. In cases where the stimulus is a cytokine or a growth factor, the cell responds by inducing modifications in the actin cytoskeleton. These changes are mediated through the Rho family of GTPases. Among these GTPases, RhoA, Rac1 and Cdc42 have been extensively studied. The activity of these proteins is closely monitored and tightly regulated through Guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) that turn the “switch” on and off respectively. Crosstalk between Rho GTPases has been long studied; yet many questions are raised regarding the spatiotemporal regulation of these GTPases, particularly RhoA and Rac1. This review sheds a light on the antagonistic relationship between both GTPases and puts emphasis on the importance of cycling of RhoA activation at the focal adhesions for optimal cell migration. en_US
dc.language.iso en en_US
dc.title Rho A and Rac1 en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Antagonists moving forward en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Tissue and Cell en_US
dc.journal.volume 65 en_US
dc.article.pages 3 en_US
dc.keywords RhoA en_US
dc.keywords Rac1 en_US
dc.keywords Migration en_US
dc.keywords Focal adhesions en_US
dc.identifier.doi https://doi.org/10.1016/j.tice.2020.101364 en_US
dc.identifier.ctation Salloum, G., Jaafar, L., & El-Sibai, M. (2020). Rho A and Rac1: Antagonists Moving Forward. Tissue and Cell, 65. en_US
dc.author.email mirvat.elsibai@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/abs/pii/S0040816620300410#kwd0005 en_US
dc.note Review Article en_US
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US
dc.author.affiliation Lebanese American University en_US

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