The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells

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dc.contributor.author Al-Koussa, Houssam
dc.contributor.author El Atat, Oula
dc.contributor.author Jaafar, Leila
dc.contributor.author Tashjian, Hagop
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2020-05-01T13:47:34Z
dc.date.available 2020-05-01T13:47:34Z
dc.date.copyright 2020 en_US
dc.date.issued 2020-05-01
dc.identifier.issn 2210-7177 en_US
dc.identifier.uri http://hdl.handle.net/10725/11878
dc.description.abstract Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which includes Rac1, Cdc42, and RhoA, is an important family whose members are key regulators of the invasion and migration of glioblastoma cells. In this review, we describe the role played by the Rho family of GTPases in the regulation of the invasion and migration of glioblastoma cells. Specifically, we focus on the role played by RhoA, Rac1, RhoG, and Cdc42 in cell migration through rearrangement of actin cytoskeleton, cell adhesion, and invasion. Finally, we highlight the importance of potentially targeting Rho GTPases in the treatment of glioblastoma. en_US
dc.language.iso en en_US
dc.title The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Analytical Cellular Pathology en_US
dc.journal.volume 2020 en_US
dc.article.pages 9 en_US
dc.identifier.doi https://doi.org/10.1155/2020/9274016 en_US
dc.identifier.ctation Al-Koussa, H., Atat, O. E., Jaafar, L., Tashjian, H., & El-Sibai, M. (2020). The role of Rho GTPases in motility and invasion of glioblastoma cells. Analytical Cellular Pathology, 2020. en_US
dc.author.email mirvat.elsibai@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.hindawi.com/journals/acp/2020/9274016/ en_US
dc.note Review Article en_US
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US
dc.author.affiliation Lebanese American University en_US

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