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dc.contributor.author Jaafar, Leila
dc.contributor.author Chamseddine, Zeinab
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2020-05-01T13:29:59Z
dc.date.available 2020-05-01T13:29:59Z
dc.date.copyright 2020 en_US
dc.date.issued 2020-05-01
dc.identifier.issn 0914-7470 en_US
dc.identifier.uri http://hdl.handle.net/10725/11877
dc.description.abstract StarD13 is a tumor suppressor and a GTPase activating protein (GAP) for Rho GTPases. Thus, StarD13 regulates cell survival pathways and induces apoptosis in a p53-dependent and independent manners. In tumors, StarD13 is either downregulated or completely inhibited, depending on the tumor type. As such, and through the dysregulation of Rho GTPases, this affects adhesion dynamics, actin dynamics, and leads to an increase or a decrease in tumor metastasis depending on the tumor grade and type. Being a key regulatory protein, StarD13 is a potential promising candidate for therapeutic approaches. This paper reviews the key characteristics of this protein and its role in tumor malignancies. en_US
dc.language.iso en en_US
dc.title StarD13 en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle a potential star target for tumor therapeutics en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Human Cell en_US
dc.article.pages 1-7 en_US
dc.keywords Cdc42 en_US
dc.keywords Rho GTPases en_US
dc.keywords RhoA en_US
dc.keywords RhoGAP en_US
dc.keywords StarD13 en_US
dc.identifier.doi https://doi.org/10.1007/s13577-020-00358-2 en_US
dc.identifier.ctation Jaafar, L., Chamseddine, Z., & El-Sibai, M. (2020). StarD13: a potential star target for tumor therapeutics. Human Cell, 1-7. en_US
dc.author.email mirvat.elsibai@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/article/10.1007%2Fs13577-020-00358-2 en_US
dc.note Review Article en_US
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US
dc.author.affiliation Lebanese American University en_US

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