The Role of Rho GTPases in VEGF Signaling in Cancer Cells

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dc.contributor.author El Baba, Nada
dc.contributor.author Farran, Mohammad
dc.contributor.author Abi Khalil, Elie
dc.contributor.author Jaafar, Leila
dc.contributor.author Fakhoury, Isabelle
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2020-05-01T13:11:57Z
dc.date.available 2020-05-01T13:11:57Z
dc.date.copyright 2020 en_US
dc.date.issued 2020-05-01
dc.identifier.issn 2210-7177 en_US
dc.identifier.uri http://hdl.handle.net/10725/11876
dc.description.abstract Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream molecular pathways have been thoroughly studied. Activation of VEGF signal transduction can be initiated by the molecules’ binding to two classes of transmembrane receptors: (1) the VEGF tyrosine kinase receptors (VEGF receptors 1 through 3) and (2) the neuropilins (NRP1 and 2). The involvement of Rho GTPases in modulating VEGFA signaling in both cancer cells and endothelial cells has also been well established. Additionally, different isoforms of Rho GTPases, namely, RhoA, RhoC, and RhoG, have been shown to regulate VEGF expression as well as blood vessel formation. This review article will explore how Rho GTPases modulate VEGF signaling and the consequences of such interaction on cancer progression. en_US
dc.language.iso en en_US
dc.title The Role of Rho GTPases in VEGF Signaling in Cancer Cells en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Analytical Cellular Pathology en_US
dc.journal.volume 2020 en_US
dc.article.pages 11 en_US
dc.identifier.doi https://doi.org/10.1155/2020/2097214 en_US
dc.identifier.ctation El Baba, N., Farran, M., Khalil, E. A., Jaafar, L., Fakhoury, I., & El-Sibai, M. (2020). The Role of Rho GTPases in VEGF Signaling in Cancer Cells. Analytical Cellular Pathology, 2020. en_US
dc.author.email mirvat.elsibai@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.hindawi.com/journals/acp/2020/2097214/ en_US
dc.note Review Article en_US
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US
dc.author.affiliation Lebanese American University en_US

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