The multiple roles and therapeutic potential of molecular chaperones in prostate cancer

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dc.contributor.author Hoter, Abdullah
dc.contributor.author Rizk, Sandra
dc.contributor.author Naim, Hassan Y.
dc.date.accessioned 2019-12-05T10:46:42Z
dc.date.available 2019-12-05T10:46:42Z
dc.date.copyright 2019 en_US
dc.date.issued 2019-12-05
dc.identifier.issn 2072-6694 en_US
dc.identifier.uri http://hdl.handle.net/10725/11608
dc.description.abstract Prostate cancer (PCa) is one of the most common cancer types in men worldwide. Heat shock proteins (HSPs) are molecular chaperones that are widely implicated in the pathogenesis, diagnosis, prognosis, and treatment of many cancers. The role of HSPs in PCa is complex and their expression has been linked to the progression and aggressiveness of the tumor. Prominent chaperones, including HSP90 and HSP70, are involved in the folding and trafficking of critical cancer-related proteins. Other members of HSPs, including HSP27 and HSP60, have been considered as promising biomarkers, similar to prostate-specific membrane antigen (PSMA), for PCa screening in order to evaluate and monitor the progression or recurrence of the disease. Moreover, expression level of chaperones like clusterin has been shown to correlate directly with the prostate tumor grade. Hence, targeting HSPs in PCa has been suggested as a promising strategy for cancer therapy. In the current review, we discuss the functions as well as the role of HSPs in PCa progression and further evaluate the approach of inhibiting HSPs as a cancer treatment strategy. en_US
dc.language.iso en en_US
dc.title The multiple roles and therapeutic potential of molecular chaperones in prostate cancer en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 199829370 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Cancers en_US
dc.journal.volume 11 en_US
dc.journal.issue 8 en_US
dc.article.pages 1194 en_US
dc.keywords Prostate cancer en_US
dc.keywords Therapeutic resistance en_US
dc.keywords Heat shock proteins (HSPs) en_US
dc.keywords Molecular chaperones en_US
dc.keywords HSPs inhibitors en_US
dc.keywords Biomakers en_US
dc.identifier.doi https://doi.org/10.3390/cancers11081194 en_US
dc.identifier.ctation Hoter, A., Rizk, S., & Naim, H. Y. (2019). The multiple roles and therapeutic potential of molecular chaperones in prostate cancer. Cancers, 11(8), 1194. en_US
dc.author.email sandra.rizk@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.mdpi.com/2072-6694/11/8/1194 en_US
dc.orcid.id https://orcid.org/0000-0002-4405-5703 en_US
dc.author.affiliation Lebanese American University en_US

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