Distinctive role of starD 13 in serous ovarian carcinoma cell proliferation, metastasis, and invadopodia assembly. (c2019)

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dc.contributor.author Abdullatef, Sandra
dc.date.accessioned 2019-11-25T09:46:17Z
dc.date.available 2019-11-25T09:46:17Z
dc.date.copyright 2019 en_US
dc.date.issued 2019-11-25
dc.date.submitted 2019-05-06
dc.identifier.uri http://hdl.handle.net/10725/11576
dc.description.abstract Ovarian carcinoma is the second most leading cause of deaths among female reproductive system malignant tumors. Serous epithelial carcinomas have a poor treatment rates for it is most likely to be advanced when diagnosed due to its poor indications and symptoms. Ovarian serous carcinomas are mainly divided into different stages according to the invasiveness and metastatic ability of the tumor. Many mutations are acquired which lead to the development of this malignancy. This occur in entities that greatly affect the cell cycle, cell signaling pathways and cell motility, which all involve the action of Rho GTPases. The protein of interest in the present study was DLC2, also known as StarD13 or START-GAP2, a GTPaseactivating protein (GAP) for Rhoa and Cdc42. Literature data indicate that this protein is considered a tumor-suppressor in hepatocellular carcinoma. Previous research in our laboratory confirmed StarD13 as a tumor suppressor in astrocytoma, in breast cancer, and in colon cancer. In this study, we aim to investigate the role of StarD13 in cell migration, invasion, and proliferation. The results show that StarD13 is a tumor suppressor in ovarian serous carcinoma, it inhibits the function of cdc42 leading to the decrease in invadopodia assembly hence hindering invasion. StarD13 is needed for cell motility via its indirect effect on RhoA activation cycle. Moreover, StarD13 knockdown increased cell adhesiveness via the crosstalk between Cdc42 and Rac1 pathway. Therefore the cells were not being able to detach and move. Establishing the conclusion that StarD13 is in fact a tumor suppressor but it is needed for cell motility in ovarian cancer. en_US
dc.language.iso en en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.subject Ovaries -- Cancer -- Treatment en_US
dc.subject GTPase-activating protein en_US
dc.title Distinctive role of starD 13 in serous ovarian carcinoma cell proliferation, metastasis, and invadopodia assembly. (c2019) en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 201206414 en_US
dc.author.commembers Khalaf, Roy
dc.author.commembers Nawas, Tarek
dc.author.department Natural Sciences en_US
dc.description.embargo 24M en_US
dc.description.physdesc 1 hard copy: xv, 64 leaves; col. ill. charts; 30 cm. available at RNL. en_US
dc.author.advisor El Sibai, Mirvat
dc.keywords StarD14 en_US
dc.keywords RhoA en_US
dc.keywords Cdc42 en_US
dc.keywords Invadopodia en_US
dc.keywords Focal Adhesions en_US
dc.keywords Ovarian Serous Carcinoma en_US
dc.keywords Motility en_US
dc.description.bibliographiccitations Bibliography: (leaves 53-64). en_US
dc.identifier.doi https://doi.org/10.26756/th.2019.142 en_US
dc.author.email sandra.abdellatef@lau.edu en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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