Cancer stem cells in neuroblastoma

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dc.contributor.author Bahmad, Hisham F.
dc.contributor.author Chamaa, Farah
dc.contributor.author Assi, Sahar
dc.contributor.author Chalhoub, Reda M.
dc.contributor.author Abou-Antoun, Tamara
dc.contributor.author Abou-Kheir, Wassim
dc.date.accessioned 2019-11-07T12:14:13Z
dc.date.available 2019-11-07T12:14:13Z
dc.date.copyright 2019 en_US
dc.date.issued 2019-11-07
dc.identifier.issn 1662-5099 en_US
dc.identifier.uri http://hdl.handle.net/10725/11502
dc.description.abstract Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in childhood. Despite intense efforts to develop a successful treatment, current available therapies are still challenged by high rates of resistance, recurrence and progression, most notably in advanced cases and highly malignant tumors. Emerging evidence proposes that this might be due to a subpopulation of cancer stem cells (CSCs) or tumor-initiating cells (TICs) found in the bulk of the tumor. Therefore, the development of more targeted therapy is highly dependent on the identification of the molecular signatures and genetic aberrations characteristic to this subpopulation of cells. This review aims at providing an overview of the key molecular players involved in NB CSCs and focuses on the experimental evidence from NB cell lines, patient-derived xenografts and primary tumors. It also provides some novel approaches of targeting multiple drivers governing the stemness of CSCs to achieve better anti-tumor effects than the currently used therapeutic agents. en_US
dc.language.iso en en_US
dc.title Cancer stem cells in neuroblastoma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle expanding the therapeutic frontier en_US
dc.author.school SOP en_US
dc.author.idnumber 201005279 en_US
dc.author.department Pharmaceutical Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Frontiers in Molecular Neuroscience en_US
dc.journal.volume 12 en_US
dc.article.pages 131 en_US
dc.keywords Neuroblastoma en_US
dc.keywords Cancer stem cells en_US
dc.keywords Molecular signatures en_US
dc.keywords Therapeutic targets en_US
dc.keywords Genetic aberrations en_US
dc.identifier.doi https://doi.org/10.3389/fnmol.2019.00131 en_US
dc.identifier.ctation Bahmad, H. F., Chamaa, F. O., Assi, S., Chalhoub, R. M., Abou-Antoun, T., & Abou-Kheir, W. (2019). Cancer Stem Cells in Neuroblastoma: Expanding the Therapeutic Frontier. Frontiers in molecular neuroscience, 12, 131. en_US
dc.author.email tamara.abouantoun@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.frontiersin.org/articles/10.3389/fnmol.2019.00131/full en_US
dc.author.affiliation Lebanese American University en_US

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