mtDNA lineages reveal coronary artery disease‐associated structures in the Lebanese population

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dc.contributor.author Haber, Marc
dc.contributor.author Youhanna, Sonia C.
dc.contributor.author Balanovsky, Oleg
dc.contributor.author Saade, Stephanie
dc.contributor.author Martínez‐Cruz, Begona
dc.contributor.author Ghassibe-Sabbagh, Michella
dc.contributor.author Shasha, Nabil
dc.contributor.author Osman, Raed
dc.contributor.author El Bayeh, Hamid
dc.contributor.author Koshel, Sergey
dc.contributor.author Zaporozhchenko, Valery
dc.contributor.author Balanovska, Elena
dc.contributor.author Soria‐Hernanz, David F.
dc.contributor.author Platt, Daniel E.
dc.date.accessioned 2019-07-22T08:20:46Z
dc.date.available 2019-07-22T08:20:46Z
dc.date.copyright 2011 en_US
dc.date.issued 2019-07-22
dc.identifier.issn 1435-232X en_US
dc.identifier.uri http://hdl.handle.net/10725/11120
dc.description.abstract Population origins and ancestry have previously been found to be important determinants of coronary artery disease (CAD). This study investigates associations of Lebanese mitochondrial DNA lineages with CAD and studies their correlation with other populations, exploring population structures that may infer mitochondria functional associations and reveal population movements and origins. Sequencing the mitochondrial hypervariable sequence 1 (HVS‐1) of 363 controls and 448 cases revealed that haplogroup W was more frequent (P= 0.013) in cases compared to controls, and was associated with increased risk of CAD (OR = 5.50, 95% CI = 1.50–35.30, P= 0.026) among Lebanese samples. Haplogroup A was only found in controls (P= 0.029). We have detected stronger geographic correlation between haplogroup W and CAD (Pearson's r= 0.316, P < 0.001) than between haplogroup A and CAD (r= 0.149, P < 0.001). HVS‐1 phylogenetic network of haplogroup W shows controls are restricted to European clusters while cases belong mostly to Middle Eastern natives. The network of haplogroup A shows that the controls belong to a cluster dominated by Central Asians. Our results show evidence of a gene flow into Lebanon, creating CAD‐associated population structures that are similar to those in the source populations, maintained by limited admixture, and probably encompassing variations on the nuclear and/or the mitochondrial genome that are correlated with the disease. en_US
dc.language.iso en en_US
dc.title mtDNA lineages reveal coronary artery disease‐associated structures in the Lebanese population en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 20030001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Annals Human Genetics en_US
dc.journal.volume 76 en_US
dc.journal.issue 1 en_US
dc.article.pages 1-8 en_US
dc.keywords Coronary artery disease en_US
dc.keywords HVS‐1 en_US
dc.keywords Lebanon en_US
dc.keywords mtDNA haplotype en_US
dc.keywords Population structure en_US
dc.identifier.doi https://doi.org/10.1111/j.1469-1809.2011.00682.x en_US
dc.identifier.ctation Haber, M., Youhanna, S. C., Balanovsky, O., Saade, S., Martínez‐Cruz, B., Ghassibe‐Sabbagh, M., ... & Zaporozhchenko, V. (2012). mtDNA Lineages Reveal Coronary Artery Disease‐Associated Structures in the Lebanese Population. Annals of human genetics, 76(1), 1-8. en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-1809.2011.00682.x en_US
dc.orcid.id https://orcid.org/0000-0002-8494-5081 en_US
dc.author.affiliation Lebanese American University en_US

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