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Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon

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dc.contributor.author Haber, Marc
dc.contributor.author Platt, Daniel E.
dc.contributor.author Khoury, Simon
dc.contributor.author Badro, Danielle A.
dc.contributor.author Abboud, Miguel
dc.contributor.author Tyler-Smith, Chris
dc.contributor.author Zalloua, Pierre
dc.date.accessioned 2019-07-22T08:08:39Z
dc.date.available 2019-07-22T08:08:39Z
dc.date.copyright 2011 en_US
dc.identifier.issn 1435-232X en_US
dc.identifier.uri http://hdl.handle.net/10725/11119
dc.description.abstract We have sought to identify signals of assimilation of African male lines in Lebanon by exploring the association of sickle cell disease (SCD) in Lebanon with Y-chromosome haplogroups that are informative of the disease origin and its exclusivity to the Muslim community. A total of 732 samples were analyzed, including 33 SCD patients from Lebanon genotyped for 28 binary markers and 19 short tandem repeats on the non-recombinant segment of the Y chromosome. Genetic organization was identified using populations known to have influenced the genetic structure of the Lebanese population, in addition to African populations with high incidence of SCD. Y-chromosome haplogroup R-M343 sub-lineages distinguish between sub-Saharan African and Lebanese Y chromosomes. We detected a limited penetration of SCD into Lebanese R-M343 carriers, restricted to Lebanese Muslims. We suggest that this penetration brought the sickle cell gene along with the African R-M343, probably with the Saharan caravan slave trade. en_US
dc.language.iso en en_US
dc.title Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 20030001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Human Genetics volume en_US
dc.journal.volume 59 en_US
dc.journal.issue 1 en_US
dc.article.pages 29-33 en_US
dc.identifier.ctation Haber, M., Platt, D. E., Khoury, S., Badro, D. A., Abboud, M., Tyler-Smith, C., & Zalloua, P. A. (2011). Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon. Journal of human genetics, 56(1), 29. en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.nature.com/articles/jhg2010131 en_US
dc.orcid.id https://orcid.org/0000-0002-8494-5081 en_US
dc.author.affiliation Lebanese American University en_US


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