.

Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls

LAUR Repository

Show simple item record

dc.contributor.author Taleb, Nadine
dc.contributor.author Bou Khalil, Pierre
dc.contributor.author Zantout, Mira S.
dc.contributor.author Zalloua, Pierre
dc.contributor.author Azar, Sami T.
dc.date.accessioned 2019-07-22T07:43:14Z
dc.date.available 2019-07-22T07:43:14Z
dc.date.copyright 2010 en_US
dc.identifier.issn 1432-5233 en_US
dc.identifier.uri http://hdl.handle.net/10725/11117
dc.description.abstract Patients with type 1 diabetes (a TH1 disease) have been reported to be at a lower risk of developing asthma (a TH2 disease). Both diseases are affected by environmental and genetic factors. Our objective is to examine this relationship in Lebanon, a Middle-Eastern country, where no previous similar studies are available. This is a cross-sectional observational study conducted at the Chronic Care Center, a referral medical center for type 1 diabetics. Patients with type 1 diabetes aged 6–39 years old, their unaffected siblings and age-matched control completed the International Primary Care Airways Group asthma screening questionnaire. The prevalence of asthma symptoms was compared among the three groups and separately within a subgroup of diabetics in relation to their carrier state of previously collected genetic data. Among 305 diabetics, 776 siblings and 187 controls, diabetics were at lower risk of having any asthma symptoms than controls; OR 0.48 (95% CI 0.32–0.72, p < 0.001) and siblings were at lower risk than diabetics and controls; OR 0.64 (95% CI 0.45–0.91, p = 0.01) and 0.28 (95% CI 0.19–0.42, p < 0.001), respectively. Among 66 diabetics, carriers of the HLA-DQB1*0201 allele were at lower risk of having any asthma symptoms than non-carriers (25.5 vs. 53.3%, p = 0.04). Only a statistically non-significant trend of higher risk was observed in carriers of HLA-DQB1*0301 and G allele at the 49 (A/G) nucleotide of CTLA-4 gene. The TH1–TH2 paradigm might partially explain these findings, since siblings were the least to report asthma symptoms. Future research is needed with diagnostic tests for asthma and extensive genetic testing. en_US
dc.language.iso en en_US
dc.title Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 20030001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Acta Diabetologica en_US
dc.journal.volume 47, supp. 1 en_US
dc.article.pages 13-18 en_US
dc.keywords Type 1 diabetes en_US
dc.keywords Asthma en_US
dc.keywords TH1/TH2 paradigm en_US
dc.keywords HLA-DQB1 en_US
dc.keywords 49 (A/G) CTLA4 en_US
dc.identifier.doi https://doi.org/10.1007/s00592-009-0108-5 en_US
dc.identifier.ctation Taleb, N., Khalil, P. B., Zantout, M. S., Zalloua, P., & Azar, S. T. (2010). Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls. Acta diabetologica, 47(1), 13-18. en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/article/10.1007/s00592-009-0108-5 en_US
dc.orcid.id https://orcid.org/0000-0002-8494-5081 en_US
dc.author.affiliation Lebanese American University en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search LAUR


Advanced Search

Browse

My Account