Recombination gives a new insight in the effective population size and the history of the old world human populations

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dc.contributor.author Mele, Marta
dc.contributor.author Javed, Asif
dc.contributor.author Pybus, Marc
dc.contributor.author Zalloua, Pierre
dc.contributor.author Haber, Marc
dc.contributor.author Comas, David
dc.contributor.author Netea, Mihai G.
dc.contributor.author Balamovsky, Oleg
dc.contributor.author Balanovska, Elena
dc.contributor.author Jin, Li
dc.contributor.author Yang, Yajun
dc.contributor.author Pitchappan, R.M.
dc.contributor.author Arunkumar, G.
dc.contributor.author Parida, Laxmi
dc.contributor.author Calafell, Francesc
dc.contributor.author Bertranpetit, Jaume
dc.date.accessioned 2019-07-22T06:47:43Z
dc.date.available 2019-07-22T06:47:43Z
dc.date.copyright 2011 en_US
dc.date.issued 2019-07-22
dc.identifier.issn 1537-1719 en_US
dc.identifier.uri http://hdl.handle.net/10725/11111
dc.description.abstract The information left by recombination in our genomes can be used to make inferences on our recent evolutionary history. Specifically, the number of past recombination events in a population sample is a function of its effective population size (Ne). We have applied a method, Identifying Recombination in Sequences (IRiS), to detect specific past recombination events in 30 Old World populations to infer their Ne. We have found that sub-Saharan African populations have an Ne that is approximately four times greater than those of non-African populations and that outside of Africa, South Asian populations had the largest Ne. We also observe that the patterns of recombinational diversity of these populations correlate with distance out of Africa if that distance is measured along a path crossing South Arabia. No such correlation is found through a Sinai route, suggesting that anatomically modern humans first left Africa through the Bab-el-Mandeb strait rather than through present Egypt. en_US
dc.language.iso en en_US
dc.title Recombination gives a new insight in the effective population size and the history of the old world human populations en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 20030001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Molecular Biology and Evolution en_US
dc.journal.volume 29 en_US
dc.journal.issue 1 en_US
dc.article.pages 25-30 en_US
dc.keywords Recombination en_US
dc.keywords Effective population size en_US
dc.keywords Out of Africa en_US
dc.identifier.doi https://doi.org/10.1093/molbev/msr213 en_US
dc.identifier.ctation Melé, M., Javed, A., Pybus, M., Zalloua, P., Haber, M., Comas, D., ... & Yang, Y. (2011). Recombination gives a new insight in the effective population size and the history of the old world human populations. Molecular biology and evolution, 29(1), 25-30. en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://academic.oup.com/mbe/article/29/1/25/1749992 en_US
dc.orcid.id https://orcid.org/0000-0002-8494-5081 en_US
dc.author.affiliation Lebanese American University en_US

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