No association between the −1031 polymorphism in the TNF-α promoter region and type 1 diabetes

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dc.contributor.author Shbaklo, Hadia
dc.contributor.author Azar, Sami T.
dc.contributor.author Terwedow, Henry
dc.contributor.author Halaby, Georges
dc.contributor.author Naja, Roy P.
dc.contributor.author Zalloua, Pierre A.
dc.date.accessioned 2019-07-22T06:22:00Z
dc.date.available 2019-07-22T06:22:00Z
dc.date.copyright 2003 en_US
dc.date.issued 2019-07-22
dc.identifier.issn 1879-1166 en_US
dc.identifier.uri http://hdl.handle.net/10725/11109
dc.description.abstract Tumor necrosis factor alpha (TNF-α) is an important immunomodulator and is believed to be involved in the development or progression of type 1 diabetes. In the following study, we evaluated TNF-α promoter polymorphisms at positions −863 and −1031 and their association with type 1 diabetes in a group of 210 diabetic patients from Lebanon. Our results show that in our population, the C allele is predominant at position −863, whereas the A allele is very rare (2%). At position −1031, however, the C and T allele distribution was similar in both the patient (17.8% vs 82.2%, respectively) and the control (21.4% vs 79.6%) groups. No association of TNF-α genotype at position 1031 with type 1 diabetes was found as demonstrated by the family-based association test and the transmission disequilibrium test. However, when patient genotypes were compared, the recessive CC genotype was only found in type 1 diabetic males but not in type 1 diabetic females. This observation, however, requires further investigation in a larger sample before conclusive association to gender is suggested. In conclusion, our results demonstrate that no association between TNF-α polymorphism and type 1 diabetes seems to exist in our population. en_US
dc.language.iso en en_US
dc.title No association between the −1031 polymorphism in the TNF-α promoter region and type 1 diabetes en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 20030001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Human Immunology en_US
dc.journal.volume 64 en_US
dc.journal.issue 6 en_US
dc.article.pages 633-638 en_US
dc.keywords Type 1 diabetes en_US
dc.keywords Stumor necrosis factor-alpha en_US
dc.keywords Polymorphism en_US
dc.keywords HLA en_US
dc.identifier.doi https://doi.org/10.1016/S0198-8859(03)00053-3 en_US
dc.identifier.ctation Shbaklo, H., Azar, S. T., Terwedow, H., Halaby, G., Naja, R. P., & Zalloua, P. A. (2003). No association between the− 1031 polymorphism in the TNF-α promoter region and type 1 diabetes. Human immunology, 64(6), 633-638. en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S0198885903000533 en_US
dc.orcid.id https://orcid.org/0000-0002-8494-5081 en_US
dc.author.affiliation Lebanese American University en_US

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