Higher serum leptin level in women than in nen with type 1 diabetes

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dc.contributor.author Azar, Sami T.
dc.contributor.author Salti, Ibrahim
dc.contributor.author Zantout, Mira S.
dc.contributor.author Shahine, Carmen H.
dc.contributor.author Zalloua, Pierre A.
dc.date.accessioned 2019-07-19T10:46:56Z
dc.date.available 2019-07-19T10:46:56Z
dc.date.copyright 2002 en_US
dc.identifier.issn 1538-2990 en_US
dc.identifier.uri http://hdl.handle.net/10725/11096
dc.description.abstract Leptin is the protein product of the obese (ob) gene, a lipostatic hormone that contributes to body weight regulation through suppressing appetite and/or stimulating energy expenditure in humans and/or rodents. In humans, serum leptin concentrations are increased in relation to increased body fat content. Studies have shown a higher leptin level in women compared with men. However, the gender influence on serum leptin concentrations has never been evaluated in patients with type 1 diabetes. In this study, serum leptin levels and percentage body fat mass were measured in men and women with type 1 diabetes. Fasting serum leptin levels were higher in women (16.7 ± 11.6 ng/mL) than in men (3.0 ± 1.5 ng/mL; P < 0.05) and were independent of exogenous insulin intake and of glucose control. Percentage body fat and fat mass were significant determinants of leptin concentration, whereas age and duration of diabetes were not related to leptin concentration. Subgroups of men (n = 12) and women (n = 11) with total body fat between 20 and 30% were compared. Leptin levels were also higher in women compared with men (13.5 ± 8.3 ng/mL versus 3.2 ± 1.7 ng/mL; P < 0.05, respectively). In conclusion, our findings indicate that gender is an important determinant of serum leptin concentration in type 1 diabetics, this gender difference is partly explained by body fat distribution and that type 1 diabetic women may be more resistant than type 1 diabetic men to leptin’s alleged lipostatic actions. en_US
dc.language.iso en en_US
dc.title Higher serum leptin level in women than in nen with type 1 diabetes en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school N/A en_US
dc.author.idnumber 20030001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal The American Journal of the Medical Sciences en_US
dc.journal.volume 323 en_US
dc.journal.issue 4 en_US
dc.article.pages 206-209 en_US
dc.keywords Leptin en_US
dc.keywords Gender en_US
dc.keywords Type 1 diabetes mellitus en_US
dc.keywords Obesity en_US
dc.keywords Body weight regulation en_US
dc.identifier.doi https://doi.org/10.1097/00000441-200204000-00007 en_US
dc.identifier.ctation Azar, S. T., Salti, I., Zantout, M. S., Shahine, C. H., & Zalloua, P. A. (2002). Higher serum leptin level in women than in men with type 1 diabetes. The American journal of the medical sciences, 323(4), 206-209. en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/abs/pii/S0002962915344797 en_US
dc.orcid.id https://orcid.org/0000-0002-8494-5081 en_US
dc.author.affiliation Lebanese American University en_US

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