Effective treatment of hypereosinophilic syndrome with imatinib mesylate

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dc.contributor.author Salem, Ziad
dc.contributor.author Zalloua, Pierre A.
dc.contributor.author Chehali, Aref
dc.contributor.author Bitar, Nizar
dc.contributor.author Abboud, Miguel
dc.contributor.author kadri, Adel
dc.contributor.author Chami, Beatrice
dc.contributor.author Bazarbachi, Ali
dc.date.accessioned 2019-07-19T06:38:17Z
dc.date.available 2019-07-19T06:38:17Z
dc.date.copyright 2003 en_US
dc.date.issued 2019-07-19
dc.identifier.issn 1466-4860 en_US
dc.identifier.uri http://hdl.handle.net/10725/11087
dc.description.abstract Imatinib mesylate treatment is highly effective in chronic myeloid leukaemia and recent data have suggested that imatinib mesylate is also effective in the treatment of idiopathic hypereosinophilicsyndrome (HES). Six patients with HES were treated daily with 100 mg imatinib mesylate. Five patients had normal karyotype and one showed trisomy 8. RT-PCR was negative for ETV6-PDGFRB and BCR-ABL fusion mRNAs. All patients rapidly achieved complete haematological remission. One patient remained in remission for more than 6 weeks after discontinuing treatment. No significant side effect was noted. Imatinib mesylate should be considered in the first-line therapy of idiopathic HES. en_US
dc.language.iso en en_US
dc.title Effective treatment of hypereosinophilic syndrome with imatinib mesylate en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 20030001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal The Hematology Journal en_US
dc.journal.volume 4 en_US
dc.journal.issue 6 en_US
dc.article.pages 410-412 en_US
dc.identifier.doi https://doi.org/10.1038/sj.thj.6200294 en_US
dc.identifier.ctation Salem, Z., Zalloua, P. A., Chehal, A., Bitar, N., Abboud, M., Kadri, A., ... & Bazarbachi, A. (2003). Effective treatment of hypereosinophilic syndrome with imatinib mesylate. The Hematology Journal, 4(6), 410-412. en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.researchgate.net/profile/Beatrice_Chami/publication/8962207_Effective_treatment_of_hypereosinophilic_syndrome_with_imatinib_mesylate/links/545868ee0cf26d5090ab62a9.pdf en_US
dc.orcid.id https://orcid.org/0000-0002-8494-5081 en_US
dc.author.affiliation Lebanese American University en_US

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