Multi-wavelength optical imaging of human tumour xenografts

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dc.contributor.author Wang, Wei
dc.contributor.author Cameron, Arlin G.
dc.contributor.author Wendt, Juliet A.
dc.contributor.author Mawad, Michel E.
dc.contributor.author Ke, Shi
dc.date.accessioned 2019-07-10T11:08:49Z
dc.date.available 2019-07-10T11:08:49Z
dc.date.copyright 2011 en_US
dc.date.issued 2019-07-10
dc.identifier.issn 1445-0038 en_US
dc.identifier.uri http://hdl.handle.net/10725/11031
dc.description.abstract In vivo optical imaging methods have become a cornerstone of pre-clinical cancer research. Genetically modified cells with fluorescent or bioluminescent reporters allow researchers to non-invasively study tumour proliferation and biochemistry over time. Target-specific fluorescent probes may be used to reveal specific tumour properties such as growth patterns, neovasculature formation, and compartmental probe absorbance. Herein, we demonstrate the simultaneous optical imaging of these tumour properties in a human neuroblastoma model. We used luciferase-positive cancer cells, a neovasculature specific fluorescent probe, and a fluorescent tumour cell target-specific agent, in conjunction with X-ray/CT for anatomical localization. These experiments revealed a detailed map of the tumour progression and biological interactions with imaging agents within the tumour. en_US
dc.language.iso en en_US
dc.title Multi-wavelength optical imaging of human tumour xenografts en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201700518 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Australian Journal of Chemistry en_US
dc.journal.volume 64 en_US
dc.journal.issue 5 en_US
dc.article.pages 625-632 en_US
dc.identifier.doi https://doi.org/10.1071/CH10449 en_US
dc.identifier.ctation Wang, W., Cameron, A. G., Wendt, J. A., Mawad, M. E., & Ke, S. (2011). Multi-wavelength Optical Imaging of Human Tumour Xenografts. Australian Journal of Chemistry, 64(5), 625-632. en_US
dc.author.email michel.mawad@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.publish.csiro.au/ch/ch10449 en_US
dc.author.affiliation Lebanese American University en_US

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