Hemodynamic relationship between intracranial aneurysm and carotid stenosis

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dc.contributor.author Jou, Liang-Der
dc.contributor.author Shaltoni, Hashem M.
dc.contributor.author Morsi, Hesham
dc.contributor.author Mawad, Michel E.
dc.date.accessioned 2019-07-10T06:00:22Z
dc.date.available 2019-07-10T06:00:22Z
dc.date.copyright 2013 en_US
dc.date.issued 2019-07-10
dc.identifier.issn 1743-1328 en_US
dc.identifier.uri http://hdl.handle.net/10725/11023
dc.description.abstract Objective: Coexistence of both an intracranial aneurysm and a stenosis at the same internal carotid artery is infrequent, but it may complicate therapeutic management of either disease. It is unclear if a stenosis plays any role in development of intracranial aneurysms. We study patients with intracranial aneurysms at our hospital and investigate if there is a relationship between a carotid stenosis and an intracranial aneurysm. Methods: Two hundred and nine patients who were treated for their intracranial aneurysms in a 2-year period were reviewed. Fifty-four patients were found to have at least one intracranial aneurysm and one intracranial or extracranial carotid stenosis. Ten of them had bilateral stenoses; 17 aneurysms were on the ipsilateral side of the stenosis, and eight on the contralateral side. Nineteen aneurysms were elsewhere. Two cases were selected for detailed computational fluid dynamics (CFD) analyses: one with an intracranial and the other with an extracranial stenosis. Results: Aneurysms on the contralateral side of a carotid stenosis are significantly larger than those aneurysms on the ipsilateral side or with bilateral stenoses (13.6 versus 6.6 mm; P < 0.01). CFD studies show that wall shear stress at the aneurysm is more likely affected by an adjacent intracranial stenosis than by an extracranial stenosis. Conclusions: Intracranial carotid aneurysms contralateral to a carotid stenosis are significantly larger than aneurysms with a carotid stenosis elsewhere. Rupture can occur on aneurysms with an extracranial carotid stenosis on the contralateral side or with an intracranial carotid stenosis on the ipsilateral side. en_US
dc.language.iso en en_US
dc.title Hemodynamic relationship between intracranial aneurysm and carotid stenosis en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle review of clinical cases and numerical analyses en_US
dc.author.school SOM en_US
dc.author.idnumber 201700518 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Neurological Research en_US
dc.journal.volume 32 en_US
dc.journal.issue 10 en_US
dc.article.pages 1083-1089 en_US
dc.keywords Cerebral aneurysms en_US
dc.keywords Carotid stenosis en_US
dc.keywords Hemodynamics en_US
dc.identifier.doi https://doi.org/10.1179/016164110X12681290831522 en_US
dc.identifier.ctation Jou, L. D., Shaltoni, H. M., Morsi, H., & Mawad, M. E. (2010). Hemodynamic relationship between intracranial aneurysm and carotid stenosis: review of clinical cases and numerical analyses. Neurological research, 32(10), 1083-1089. en_US
dc.author.email michel.mawad@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.tandfonline.com/doi/abs/10.1179/016164110X12681290831522 en_US
dc.author.affiliation Lebanese American University en_US

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