Timing and size of flow impingement in a giant intracranial aneurysm at the internal carotid artery

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dc.contributor.author Jou, Liang-Der
dc.contributor.author Mawad, Michel E.
dc.date.accessioned 2019-07-10T05:37:28Z
dc.date.available 2019-07-10T05:37:28Z
dc.date.copyright 2011 en_US
dc.date.issued 2019-07-10
dc.identifier.issn 1741-0444 en_US
dc.identifier.uri http://hdl.handle.net/10725/11019
dc.description.abstract Flow impingement is regarded as a key factor for aneurysm formation and rupture. Wall shear stress (WSS) is often used to evaluate flow impingement even though WSS and impinging force are in two different directions; therefore, this raises an important question of whether using WSS for evaluation of flow impingement size is appropriate. Flow impinging behavior in a patient-specific model of a giant aneurysm (GA) at the internal carotid artery (ICA) was analyzed by computational fluid dynamics simulations. An Impingement Index (IMI) was used to evaluate the timing and size of flow impingement. In theory, the IMI is related to the WSS gradient, which is known to affect vascular biology of endothelial cells. Effect of non-Newtonian fluid, aneurysm size, and heart rate were also studied. Maximum WSS is found to be proportional to the IMI, but the area of high wall shear is not proportional to the size of impingement. A faster heart rate or larger aneurysm does not produce a larger impinging site, and the Newtonian assumption overestimates the size of impingement. Flow impingement at the dome occurs approximately 0.11 s after the peak of flow waveform is attained. This time delay also increases with aneurysm size and varies with heart rate and waveform. en_US
dc.language.iso en en_US
dc.title Timing and size of flow impingement in a giant intracranial aneurysm at the internal carotid artery en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201700518 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Medical & Biological Engineering & Computing en_US
dc.journal.volume 49 en_US
dc.journal.issue 8 en_US
dc.article.pages 891-899 en_US
dc.keywords Aneurysm en_US
dc.keywords Intracranial aneurysm en_US
dc.keywords Blood flow en_US
dc.identifier.doi https://doi.org/10.1007/s11517-010-0727-6 en_US
dc.identifier.ctation Jou, L. D., & Mawad, M. E. (2011). Timing and size of flow impingement in a giant intracranial aneurysm at the internal carotid artery. Medical & biological engineering & computing, 49(8), 891-899. en_US
dc.author.email michel.mawad@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/article/10.1007/s11517-010-0727-6 en_US
dc.author.affiliation Lebanese American University en_US

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