Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach

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dc.contributor.author Jour, Liang-Der
dc.contributor.author Mawad, Michel E.
dc.date.accessioned 2019-07-10T05:18:05Z
dc.date.available 2019-07-10T05:18:05Z
dc.date.copyright 2009 en_US
dc.identifier.issn 1475-925X en_US
dc.identifier.uri http://hdl.handle.net/10725/11017
dc.description.abstract Background Understanding aneurysm growth rate allows us to predict not only the current rupture risk, but also accumulated rupture risk in the future. However, determining growth rate of unruptured intracranial aneurysms often requires follow-up of patients for a long period of time so that significant growth can be observed and measured. We investigate a relationship between growth rate and rupture rate and develop a theoretical model that can predict average behavior of unruptured intracranial aneurysms based on existing clinical data. Methods A mathematical model is developed that links growth rate and rupture rate. This model assumes a stable aneurysm size distribution so the number of aneurysm ruptures is balanced by the growth of aneurysms. Annual growth rates and growth profiles are calculated from a hypothetical size distribution and data from a previous clinical study. Results Our model predicts a growth rate of 0.34–1.63 mm/yr for three different growth models when the rupture rate at 10 mm is 1%. The growth rate is 0.56–0.65 mm/yr if annual rupture rate averaged over all aneurysm sizes is assumed to be 2%. The peak of aneurysm size distribution coincides with a period of slow growth between 5 mm and 8 mm. Conclusion This mathematical model can be used to predict aneurysm growth rate, and the results are consistent with previous clinical studies. Predictions from both hypothetical and clinical cases agree very well. This model explains why some aneurysms may grow into a stable size and remain so without rupture. en_US
dc.language.iso en en_US
dc.title Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201700518 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal BioMedical Engineering OnLine en_US
dc.journal.volume 8 en_US
dc.journal.issue 1 en_US
dc.article.pages 11 en_US
dc.keywords Intracranial aneurysm en_US
dc.keywords Aneurysm growth rate en_US
dc.keywords Unruptured aneurysm en_US
dc.keywords Aneurysm size en_US
dc.keywords Previous clinical study en_US
dc.identifier.doi https://doi.org/10.1186/1475-925X-8-11 en_US
dc.identifier.ctation Jou, L. D., & Mawad, M. E. (2009). Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach. Biomedical engineering online, 8(1), 11. en_US
dc.author.email michel.mawad@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/1475-925X-8-11 en_US
dc.author.affiliation Lebanese American University en_US

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