A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain

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dc.contributor.author Wang, Wei
dc.contributor.author Ke, Shi
dc.contributor.author Kwon, Sunkuk
dc.contributor.author Yallampalli, Sasidhar
dc.contributor.author Cameron, Arlin G.
dc.contributor.author Adams, Kristen E.
dc.contributor.author Mawad, Michel E.
dc.contributor.author Sevick-Muraca, Eva M.
dc.date.accessioned 2019-07-08T11:05:19Z
dc.date.available 2019-07-08T11:05:19Z
dc.date.copyright 2007 en_US
dc.date.issued 2019-07-08
dc.identifier.issn 1520-4812 en_US
dc.identifier.uri http://hdl.handle.net/10725/10999
dc.description.abstract Optical imaging has great potential for studying molecular recognitions both in vivo and in vitro, yet nuclear imaging is the most effective clinical molecular imaging modality. The combination of optical and nuclear imaging modalities may provide complementary information for improving diagnosis and management of diseases. In this study we developed an optical and nuclear dual-labeled imaging agent, 111In-DTPA-Bz-NH-SA-K(IR-783-S-Ph-CO)-c(CGRRAGGSC)NH2, called DLIA-IL11Rα. 111In-DTPA-Bz-NH-SA is the radiotracer moiety; a near-infrared dye IR-783-S-Ph-COOH serves as the fluorescent emitter; and the cyclic peptide c(CGRRAGGSC), which is known to target interleukin 11 receptor alpha-chain (IL-11Rα), delivers the desired imaging agent to its target. Experiments revealed that the cyclic peptide c(CGRRAGGSC) continued to possess the targeting capability to IL-11Rα after the conjugation of the optical and nuclear tracers. Furthermore, the presence of the metal isotope chelator did not cause quenching of fluorescence emission. The cross validation and direct comparison of optical and nuclear imaging of a tumor was achieved using a single injection, and the preliminary results show the conjugate has tumor targeting capabilities in vivo. en_US
dc.language.iso en en_US
dc.title A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201700518 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Bioconjugate Chemistry en_US
dc.journal.volume 18 en_US
dc.journal.issue 2 en_US
dc.article.pages 397-402 en_US
dc.identifier.doi https://doi.org/10.1021/bc0602679 en_US
dc.identifier.ctation Wang, W., Ke, S., Kwon, S., Yallampalli, S., Cameron, A. G., Adams, K. E., ... & Sevick-Muraca, E. M. (2007). A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain. Bioconjugate chemistry, 18(2), 397-402. en_US
dc.author.email michel.mawad@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://pubs.acs.org/doi/abs/10.1021/bc0602679 en_US
dc.author.affiliation Lebanese American University en_US

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