Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils

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dc.contributor.author Mawad, Michel E.
dc.contributor.author Mawad, Janine K.
dc.contributor.author Carterwright, Joiner
dc.contributor.author Gokaslan, Ziya
dc.date.accessioned 2019-07-08T09:41:27Z
dc.date.available 2019-07-08T09:41:27Z
dc.date.copyright 1995 en_US
dc.date.issued 2019-07-08
dc.identifier.issn 1936-959X en_US
dc.identifier.uri http://hdl.handle.net/10725/10993
dc.description.abstract PURPOSE To evaluate the long-term histologic changes, including those in the ultrastructure of the neoendothelium, occurring in experimental canine aneurysms obliterated with Guglielmi detachable coils. METHODS Ten experimental aneurysms were surgically created in mongrel dogs using side-to-side jugular carotid fistulas that were subsequently ligated to form blind pouch venous aneurysms dependent on the carotid circulation. The aneurysms were obliterated with Guglielmi detachable coils, and the animals were kept in observation. Six months after the endovascular obliteration of the aneurysms, repeat carotid arteriography was performed to assess for potential recanalization of the aneurysms. The animals were then killed and submitted for autopsy. The carotid artery and the embolized aneurysm were resected and studied with light and electron microscopy. RESULTS Both completely obliterated and recanalized aneurysms were excluded from the parent circulation by an endothelialized layer of connective tissue. The fundus of the aneurysm was completely obliterated by heavy reactive fibrous tissue surrounding the coils with very minimal, if any, inflammatory reaction. The neointima is composed of three well-identifiable layers, the most superficial of which is formed of new endothelial cells positioned next to each other in a cobblestone fashion over a basal membrane. CONCLUSION In the absence of histologic data in human aneurysms obliterated with Guglielmi detachable coils, several observations made in our experimental study help in the understanding of the long-term results expected from this endovascular technique. en_US
dc.language.iso en en_US
dc.title Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201700518 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal American Journal of Neuroradiology en_US
dc.journal.volume 16 en_US
dc.journal.issue 1 en_US
dc.article.pages 7-13 en_US
dc.identifier.ctation Mawad, M. E., Mawad, J. K., Cartwright, J., & Gokaslan, Z. (1995). Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils. American journal of neuroradiology, 16(1), 7-13. en_US
dc.author.email michel.mawad@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.ajnr.org/content/16/1/7.short en_US
dc.author.affiliation Lebanese American University en_US

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