.

The papillomacular fold in posterior microphthalmos

LAUR Repository

Show simple item record

dc.contributor.author Nowilaty, Sawsan
dc.contributor.author Mousa, Ahmed
dc.contributor.author Ghazi, Nicola
dc.date.accessioned 2019-06-21T09:31:37Z
dc.date.available 2019-06-21T09:31:37Z
dc.date.copyright 2013 en_US
dc.identifier.issn 1552-5783 en_US
dc.identifier.uri http://hdl.handle.net/10725/10890
dc.description.abstract FREE ARVO Annual Meeting Abstract | June 2013 The Papillomacular Fold in Posterior Microphthalmos: New Insights Based on Novel Spectral-Domain Optical Coherence Tomography Findings Sawsan Nowilaty; Ahmed Mousa; Nicola Ghazi Author Affiliations & Notes Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5819. doi: SHARE E-MAIL FACEBOOK TWITTER GOOGLE DIGG DELICIOUS CITEULIKE TUMBLR STUMBLEUPON TOOLS ALERTS GET CITATION GET PERMISSIONS Abstract Purpose: To characterize using spectral-domain optical coherence tomography (SD-OCT), the internal structure of the papillomacular fold in posterior microphthalmos (PM) and analyze the posterior pole curvature in PM and its relationship to the axial length (AL) and the papillomacular fold features and pathogenesis. Methods: Forty PM eyes (20 patients) and 70 control eyes (35 subjects) underwent AL biometry (IOLMaster) and macular SD-OCT (Spectralis). SD-OCT features analyzed included the papillomacular neurosensory retinal fold’s internal structure, height and protrusion, and a novel parameter termed the “posterior pole curvature index (PPCI)” measured along the vertical and horizontal meridians. The relationship of the PPCI to the papillomacular fold height and AL, as well as to the PPCI of controls was analyzed. Results: All papillomacular folds, regardless of their height, were horizontal and invariably partial thickness sparing the photoreceptor layer, inner segment/outer segment junction, external limiting membrane, and outer nuclear layer. The retinal stratification was preserved within the fold. There was no foveal depression. Papillomacular folds harbored clinically-invisible inner nuclear layer cysts in 50%, additional clinically-visible ganglion cell layer cysts in 35% and surface corrugations with prominent vitreous in 65% of cases. PM eyes had notably larger vertical and horizontal PPCIs than controls (vPPCI mean 173 vs. 13μ; hPPCI 118 vs. 15μ, p < 0.0001 for both). Moreover, in all PM eyes, but not in controls, the vertical PPCI was notably larger than the horizontal PPCI (mean difference of 55μ, p <0.0001) and correlated strongly with inverse AL (R= -0.71, p <0.0001) and papillomacular fold height and protrusion (R= 0.68, p <0.0001). Papillomacular fold height and protrusion also correlated strongly with inverse AL (R = -0.62, p <0.0001). Conclusions: The papillomacular fold in posterior microphthalmos is consistently partial thickness, horizontally oriented with predictable internal and surface anatomical features. The posterior pole curvature in PM is invariably steep, particularly along the vertical meridian, and correlates strongly with the inverse axial length and the papillomacular fold height and protrusion. These findings may offer novel clues for the pathogenesis and consistent horizontal orientation of the papillomacular fold. en_US
dc.language.iso en en_US
dc.title The papillomacular fold in posterior microphthalmos en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle new insights based on novel spectral-domain optical coherence tomography findings en_US
dc.author.school SOM en_US
dc.author.idnumber 201000154 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Investigative Ophthalmology & Visual Science en_US
dc.journal.volume 54 en_US
dc.journal.issue 15 en_US
dc.article.pages 5819 en_US
dc.keywords 547 hyperopia en_US
dc.keywords 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) en_US
dc.keywords 585 macula/fovea en_US
dc.identifier.ctation Nowilaty, S., Mousa, A., & Ghazi, N. (2013). The Papillomacular Fold in Posterior Microphthalmos: New Insights Based on Novel Spectral-Domain Optical Coherence Tomography Findings. Investigative Ophthalmology & Visual Science, 54(15), 5819-5819. en_US
dc.author.email nicola.ghazi@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://iovs.arvojournals.org/article.aspx?articleid=2150807 en_US
dc.author.affiliation Lebanese American University en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search LAUR


Advanced Search

Browse

My Account