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A conjunctival lesion with histological features similar to large‐cell acanthoma of the skin

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A conjunctival lesion with histological features similar to large‐cell acanthoma of the skin

Ghazi, Nicola G.; Patel, Bina S.; Olsakovsky, Leslie A.; White, Kevin; Patterson, James W.; Carter, Bruce
URI: http://hdl.handle.net/10725/10857
URL: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-0560.2009.01409.x
DOI: https://doi.org/10.1111/j.1600-0560.2009.01409.x
Date: 2019-06-19
Terms of Use: This item is made available under the terms and conditions applicable to " Article ", as set forth at: http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php

Abstract:

Large‐cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed of large keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currently believed to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in the conjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential.

Citation:

Ghazi, N. G., Patel, B. S., Olsakovsky, L. A., White, K., Patterson, J. W., & Carter, B. (2010). A conjunctival lesion with histological features similar to large‐cell acanthoma of the skin. Journal of cutaneous pathology, 37(10), 1103-1106.

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