Fundus autofluorescence imaging in hereditary retinal diseases

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dc.contributor.author Pichi, Francesco
dc.contributor.author Abboud, Emad B.
dc.contributor.author Ghazi, Nicola G.
dc.contributor.author Khan, Arif O.
dc.date.accessioned 2019-06-18T08:12:53Z
dc.date.available 2019-06-18T08:12:53Z
dc.date.copyright 2017 en_US
dc.date.issued 2019-06-18
dc.identifier.uri http://hdl.handle.net/10725/10850
dc.description.abstract Fundus autofluorescence (FAF) is a non‐invasive retinal imaging modality used in clinical practice to non‐invasively map changes at the level of the retinal pigment epithelium (RPE)/photoreceptor complex and alterations of macular pigment distribution. This imaging method is based on the visualization of intrinsic fluorophores and may be easily and rapidly used in routine patient care. Excessive accumulation of lipofuscin granules in the lysosomal compartment of RPE cells represents a common downstream pathogenic pathway in various hereditary and complex retinal diseases. The clinical applications of FAF continue to expand. It is now an essential tool for evaluating macular dystrophies and various hereditary retinal disorders. Fundus autofluorescence (FAF) may detect abnormalities beyond those detected on funduscopic examination, fluorescein angiography (FA) or optical coherence tomography (OCT). Fundus autofluorescence (FAF) imaging is particularly helpful for differential diagnosis, detection and extent delineation of involved retinal areas, genotype‐phenotype correlations and monitoring of changes overtime. Given its ease of use, non‐invasive nature and value in characterizing retinal disease, FAF enjoys increasing clinical relevance. This review summarizes basic principles and FAF findings in various hereditary retinal diseases. en_US
dc.language.iso en en_US
dc.title Fundus autofluorescence imaging in hereditary retinal diseases en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201000154 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Acta Ophtalmologica en_US
dc.journal.volume 96 en_US
dc.journal.issue 5 en_US
dc.article.pages e549-e561 en_US
dc.identifier.doi https://doi.org/10.1111/aos.13602 en_US
dc.identifier.ctation Pichi, F., Abboud, E. B., Ghazi, N. G., & Khan, A. O. (2018). Fundus autofluorescence imaging in hereditary retinal diseases. Acta ophthalmologica, 96(5), e549-e561. en_US
dc.author.email nicola.ghazi@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://onlinelibrary.wiley.com/doi/full/10.1111/aos.13602 en_US
dc.author.affiliation Lebanese American University en_US

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