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Optical coherence tomography findings in persistent diabetic macular edema

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dc.contributor.author Ghazi, Nicola G.
dc.contributor.author Ciralsky, Jessica B.
dc.contributor.author Shah, Syed M.
dc.contributor.author Campochiaro, Peter A.
dc.contributor.author Haller, Julia A.
dc.date.accessioned 2019-06-13T10:00:46Z
dc.date.available 2019-06-13T10:00:46Z
dc.date.copyright 2007 en_US
dc.identifier.issn 1879-1891 en_US
dc.identifier.uri http://hdl.handle.net/10725/10800
dc.description.abstract Purpose To assess the optical coherence tomography (OCT) characteristics of eyes with persistent clinically significant diabetic macular edema (PDME) after focal laser treatment, with emphasis on the vitreomacular interface (VMI) characteristics. Design Prospective, observational case series. Methods Fifty eyes with PDME after at least one focal laser treatment were enrolled prospectively. Slit-lamp biomicroscopy, stereoscopic fundus photography, fluorescein angiography (FA), and OCT were performed for each eye. The main outcome measures included the detection rate of VMI abnormalities (VMIA) by OCT in comparison with biomicroscopy, fundus photography, and FA (traditional techniques); the relationship between VMIA and the number of focal laser sessions per eye and FA leakage pattern. Results Two of 50 eyes were excluded because of incomplete data. For the remaining 48 eyes, 25 eyes (52.1%) demonstrated definite VMIA, including anomalous vitreal adhesions, epiretinal membrane (ERM), or both, and six eyes (12.5%) had questionable VMIA. OCT in general was 1.94 times more sensitive than traditional techniques combined in detecting VMIA (P = .00003). The number of focal laser sessions and diffuse FA leakage were not associated with an increased prevalence of VMIA (P = .13 and P = .47, respectively). Conclusions This study demonstrates a high prevalence of VMIA in eyes with PDME after focal laser treatment and underscores the superiority of OCT in detecting these abnormalities. OCT evaluation of eyes with PDME may be helpful in identifying VMIA, which may impact treatment selection and patient subgroup stratification. en_US
dc.language.iso en en_US
dc.title Optical coherence tomography findings in persistent diabetic macular edema en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle the vitreomacular interface en_US
dc.author.school SOM en_US
dc.author.idnumber 201000154 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal American Journal of Ophthalmology en_US
dc.journal.volume 144 en_US
dc.journal.issue 5 en_US
dc.article.pages 747-754.e2 en_US
dc.identifier.doi https://doi.org/10.1016/j.ajo.2007.07.012 en_US
dc.identifier.ctation Ghazi, N. G., Ciralsky, J. B., Shah, S. M., Campochiaro, P. A., & Haller, J. A. (2007). Optical coherence tomography findings in persistent diabetic macular edema: the vitreomacular interface. American journal of ophthalmology, 144(5), 747-754. en_US
dc.author.email nicola.ghazi@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S0002939407006344 en_US
dc.author.affiliation Lebanese American University en_US


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