Beyond the Milan criteria

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dc.contributor.author De Carlis, Luciano
dc.contributor.author Di Sandro, Stefano
dc.contributor.author Giacomoni, Alessandro
dc.contributor.author Slim, Abdallah
dc.contributor.author Lauterio, Andrea
dc.contributor.author Mangoni, Iacopo
dc.contributor.author Mihaylov, Plamen
dc.contributor.author Pirotta, Vincenzo
dc.contributor.author Aseni, Paolo
dc.contributor.author Rampoldi, Antonio
dc.date.accessioned 2019-06-11T11:07:20Z
dc.date.available 2019-06-11T11:07:20Z
dc.date.copyright 2012 en_US
dc.date.issued 2019-06-11
dc.identifier.issn 1539-2031 en_US
dc.identifier.uri http://hdl.handle.net/10725/10777
dc.description.abstract Background To date the selection of the best candidates for liver transplantation (LT) owing to hepatocellular carcinoma (HCC) has been mainly based on tumor morphological characteristics (nodule diameter and number), which have resulted to be independent risk factors for short long-term survival and a high rate of tumor recurrence. Methods The study cohort included 118 patients among the 166 with HCC transplanted at our unit from January 2000 to December 2007. Patients were classified according to response to locoregional treatments before LT: progressive Group A; complete Group B; partial Group C; stable Group D. Results The 3-year and 5-year overall survival rates were 65.5% and 48.9% for Group A versus 84.8% and 74.6% for Group BCD (P = 0.01). The 3-year and 5-year disease-free survival rates were 74% and 74% for Group A and 95.7% and 93% for Group BCD (P = 0.007). HCC progression was the only independent risk factor according to Cox regression P = 0.014--odds ratio 4.4 (1.35-14.3). Conclusion After aggressive HCC treatment before LT, imaging progression while on the waiting list was a strong predictor of high HCC recurrence rate also in patients who met the Milan criteria. Lack of imaging progression can contribute toward the selection of good transplant candidates for HCC together with the Milan criteria. en_US
dc.language.iso en en_US
dc.title Beyond the Milan criteria en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle what risks for patients with hepatocellular carcinoma progression before liver transplantation? en_US
dc.author.school SOM en_US
dc.author.idnumber 201801809 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Clinical Gastroenterology en_US
dc.journal.volume 46 en_US
dc.journal.issue 1 en_US
dc.article.pages 78-86 en_US
dc.keywords Hepatocellular carcinoma
dc.keywords Locoregional treatment
dc.keywords Tumor progression
dc.identifier.doi https://doi.org/10.1097/MCG.0b013e31822b36f6 en_US
dc.identifier.ctation De Carlis, L., Di Sandro, S., Giacomoni, A., Slim, A., Lauterio, A., Mangoni, I., ... & Rampoldi, A. (2012). Beyond the Milan criteria: what risks for patients with hepatocellular carcinoma progression before liver transplantation?. Journal of clinical gastroenterology, 46(1), 78-86. en_US
dc.author.email abdallah.slim@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://europepmc.org/article/med/21897282 en_US
dc.author.affiliation Lebanese American University en_US

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