Should we still offer split‐liver transplantation for two adult recipients? A retrospective study of our experience

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dc.contributor.author Giacomoni, Alessandro
dc.contributor.author Lauterio, Andrea
dc.contributor.author Donadon, Matteo
dc.contributor.author De Gasperi, Andrea
dc.contributor.author Belli, Luca
dc.contributor.author Slim, Abdallah
dc.contributor.author Dorobantu, Bogdan
dc.contributor.author Mangoni, Iacopo
dc.contributor.author De Carlis, Luciano
dc.date.accessioned 2019-06-11T10:59:44Z
dc.date.available 2019-06-11T10:59:44Z
dc.date.copyright 2008 en_US
dc.date.issued 2019-06-11
dc.identifier.issn 1527-6473 en_US
dc.identifier.uri http://hdl.handle.net/10725/10776
dc.description.abstract The role of split-liver transplantation (SLT) for two adult recipients is still a matter of debate, and no agreement exists on indications, surgical techniques, and results. The aim of this study was to retrospectively analyze the outcome of our series of SLT. From May 1999 to December 2006, 16 patients underwent SLT at our unit. We used 9 full right grafts (segments 5-8) and 7 full left grafts (segments 1-4). The splitting procedure was always carried out in situ with a fully perfused liver. Postoperative complications were recorded in 8 (50%) patients: 5 (55%) in full right grafts and 3 (43%) in full left grafts. No one was retransplanted. After a median follow-up of 55.82 months (range, 0.4-91.2), 5 (31%) patients died, and the 1-, 3-, and 5-year overall survival rate for patients and grafts was 69%. We considered as a control group for the global outcome 232 whole liver transplantations performed at our unit in the same period of time. Postoperative complications were recorded in 53 (23%) patients, and after a median follow-up of 57.37 months (mean, 55.11; range, 1-102.83), the 1-, 3-, and 5-year overall patient survival was 87%, 82%, and 80%, respectively. In conclusion, SLT for two adult recipients is a technically demanding procedure that requires complex logistics and surgical teams experienced in both liver resection and transplantation. Although the reported rate of survival might be adequate for such a procedure, more efforts have to be made to improve the short-term outcome, which is inadequate in our opinion. The true feasibility of SLT for two adults has to be considered as still under investigation. en_US
dc.language.iso en en_US
dc.title Should we still offer split‐liver transplantation for two adult recipients? A retrospective study of our experience en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201801809 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Liver Transplantation en_US
dc.journal.volume 14 en_US
dc.article.pages 999-1006 en_US
dc.identifier.doi https://doi.org/10.1002/lt.21466
dc.identifier.ctation Giacomoni, A., Lauterio, A., Donadon, M., De Gasperi, A., Belli, L., Slim, A., ... & De Carlis, L. (2008). Should we still offer split‐liver transplantation for two adult recipients? A retrospective study of our experience. Liver Transplantation, 14(7), 999-1006. en_US
dc.author.email abdallah.slim@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/lt.21466 en_US
dc.author.affiliation Lebanese American University en_US

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