Liver transplantation for hepatocellular cancer

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dc.contributor.author De Carlis, Luciano
dc.contributor.author Giacomoni, Alessandro
dc.contributor.author Lauterio, Andrea
dc.contributor.author Slim, Abdallah
dc.contributor.author Sammartino, Cinzia
dc.contributor.author Pirotta, Vincenzo
dc.contributor.author Collela, Giovanni
dc.contributor.author Forti, Domencio
dc.date.accessioned 2019-06-11T10:32:23Z
dc.date.available 2019-06-11T10:32:23Z
dc.date.copyright 2005 en_US
dc.date.issued 2019-06-11
dc.identifier.issn 1432-2277 en_US
dc.identifier.uri http://hdl.handle.net/10725/10774
dc.description.abstract Liver transplantation (LTx) is the best treatment for hepatocellular carcinoma (HCC), but should be offered only to selected patients. The usual procedure is to transplant only for small and unilobular tumors. The aim of this paper is to verify whether the actual indication criteria are still justified. The details of 121 patients with HCC who were submitted to LTx from 1985 to 2000 were analyzed. Age, gender, liver disease, Child class, α‐fetoprotein (AFP) level, presence of tumor capsule, vascular invasion, size and number of nodules, histological grade, and pTNM were considered. The 5‐ and 10‐year actuarial survival rates were 61.7% and 53.1%. Freedom from recurrence was 85.9% and 85.9%, respectively. At univariate analysis, size, presence of capsule, AFP levels, vascular invasion, grade, pTNM, transarterial chemoembolization (TACE), Child class, and age were all significantly related to survival and/or cancer recurrence. Presence of capsule, AFP levels, and viral cirrhosis were independent variables in Cox's analysis for survival, whereas histological grade, AFP levels, and vascular invasion were significant independent variables for recurrence. In conclusion, a strict selection should be made to optimize graft allocation while size and multifocality should probably no longer be considered a contraindication for LTx. Histological grade, AFP levels, and vascular invasion, as indicator of tumor behavior, more likely reflect the risk of recurrence. en_US
dc.language.iso en en_US
dc.title Liver transplantation for hepatocellular cancer en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle should the current indication criteria be changed? en_US
dc.author.school SOM en_US
dc.author.idnumber 201801809 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Transplant International en_US
dc.journal.volume 16 en_US
dc.journal.issue 2 en_US
dc.article.pages 115-122 en_US
dc.keywords Liver transplantation en_US
dc.keywords Hepatocellular carcinoma en_US
dc.keywords Indication criteria en_US
dc.keywords Transarterial chemoembolization en_US
dc.identifier.doi https://doi.org/10.1111/j.1432-2277.2003.tb00272.x en_US
dc.identifier.ctation De Carlis, L., Giacomoni, A., Lauterio, A., Slim, A., Sammartino, C., Pirotta, V., ... & Forti, D. (2003). Liver transplantation for hepatocellular cancer: should the current indication criteria be changed? Transplant International, 16(2), 115-122. en_US
dc.author.email abdallah.slim@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1432-2277.2003.tb00272.x en_US
dc.author.affiliation Lebanese American University en_US

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