Type II diabetes mellitus and hyperhomocysteinemia

LAUR Repository

Show simple item record

dc.contributor.author Platt, Daniel E.
dc.contributor.author Hariri, Essa
dc.contributor.author Salameh, Pascale
dc.contributor.author Merhi, Mahmoud
dc.contributor.author Sabbah, Nada
dc.contributor.author Helou, Mariana
dc.contributor.author Mouzaya, Francis
dc.contributor.author Nemr, Rita
dc.contributor.author Al-Sarraj, Yasser
dc.contributor.author El-Shanti, Hatem
dc.contributor.author Abchee, Antoine B.
dc.contributor.author Zalloua, Pierre A.
dc.date.accessioned 2019-06-03T08:45:32Z
dc.date.available 2019-06-03T08:45:32Z
dc.date.copyright 2017 en_US
dc.date.issued 2019-06-03
dc.identifier.issn 1758-5996 en_US
dc.identifier.uri http://hdl.handle.net/10725/10734
dc.description.abstract Background Elevated homocysteine (Hc) levels have a well-established and clear causal relationship to epithelial damage leading to coronary artery disease. Furthermore, it is strongly associated with other metabolic syndrome variables, such as hypertension, which is correlated with type II diabetes mellitus (T2DM). Studies on T2DM in relation to Hc levels have shown both positive and negative associations. The aim of the present study is to examine the relationship between Hc levels and risk of T2DM in the Lebanese population. Methods We sought to identify whether Hc associates positively or negatively with diabetes in a case–control study, where 2755 subjects enrolled from patients who had been catheterized for coronary artery diagnosis and treatment. We further sought to identify whether the gene variant MTHFR 667C>T is associated with T2DM, and how Hc and MTHFR 667C>T also impact other correlates of T2DM, including the widely used diuretics in this study population. Results We found that Hc levels were significantly reduced among subjects with diabetes compared to those without diabetes when adjusted for all potential confounders (OR 0.640; 95% CI [0.44–0.92]; p = 0.0200). The associations between Hc levels and other variates contradicted the result: hypertension associates positively with high Hc levels, and with T2DM. The MTHFR 667C>T only associated significantly with high Hc levels. Conclusion These results suggest population-specific variations among a range of mechanisms that modulate the association of Hc and T2DM, providing a probe for future studies. en_US
dc.language.iso en en_US
dc.title Type II diabetes mellitus and hyperhomocysteinemia en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle a complex interaction en_US
dc.author.school SOM en_US
dc.author.idnumber 201506249 en_US
dc.author.idnumber 201004815 en_US
dc.author.idnumber 200300001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Diabetology & Metabolic Syndrome en_US
dc.journal.volume 9 en_US
dc.journal.issue 19 en_US
dc.identifier.doi https://doi.org/10.1186/s13098-017-0218-0 en_US
dc.identifier.ctation Platt, D. E., Hariri, E., Salameh, P., Merhi, M., Sabbah, N., Helou, M., ... & Abchee, A. B. (2017). Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction. Diabetology & metabolic syndrome, 9(1), 19. en_US
dc.author.email mariana.helou@lau.edu.lb en_US
dc.author.email rita.nemr@lau.edu.lb en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-017-0218-0 en_US
dc.orcid.id https://orcid.org/0000-0002-8494-5081 en_US
dc.author.affiliation Lebanese American University en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search LAUR

Advanced Search


My Account