Intractable cough and abnormal pulmonary function in benign recurrent intrahepatic cholestasis

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dc.contributor.author Chatila, Rajaa
dc.contributor.author Bergasa, Nora V.
dc.contributor.author Lagarde, Suzanne
dc.contributor.author Brain, West A.
dc.date.accessioned 2019-05-30T09:00:28Z
dc.date.available 2019-05-30T09:00:28Z
dc.date.copyright 1996 en_US
dc.date.issued 2019-05-30
dc.identifier.issn 1572-0241 en_US
dc.identifier.uri http://hdl.handle.net/10725/10704
dc.description.abstract Benign recurrent intrahepatic cholestasis (BRIC) is a syndrome characterized by recurrent episodes of cholestasis with associated pruritus. The intensity and duration of cholestatic episodes, and the length of the intervening periods, vary. unpredictably. We report the case of a patient with BRIC who was incapacitated by a severe intractable cough that accompanied marked pruritus during her second cholestatic episode. No cause for the cough was found, and it resolved spontaneously with amelioration of mild restrictive abnormalities of pulmonary function as the cholestasis subsided. Although cough has not been recognized as a complication of cholestasis, we postulate that it may occur either (i) as a result of direct stimulation of sensory nerves by circulating humoral substances related to the cholestasis that act either peripherally in the airways or centrally, or (ii) through stimulation of the vagus nerve in the liver, leading to cough that is mediated either centrally or by reflex. en_US
dc.language.iso en en_US
dc.title Intractable cough and abnormal pulmonary function in benign recurrent intrahepatic cholestasis en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200902750 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal American Journal of Gastroenterology en_US
dc.journal.volume 91 en_US
dc.journal.issue 10 en_US
dc.article.pages 2215-2219 en_US
dc.identifier.ctation Chatila, R., Bergasa, N. V., Lagarde, S., & West, A. B. (1996). Intractable cough and abnormal pulmonary function in benign recurrent intrahepatic cholestasis. American Journal of Gastroenterology, 91(10). en_US
dc.author.email rajaa.chatila@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://web.a.ebscohost.com/abstract?site=ehost&scope=site&jrnl=00029270&AN=16103824&h=Zea0h89HMudjLG6jnmWF6c8U7v1EK9Oi3vzYFd2L9qzAEUexs4hEN6G3GErnUyMtKqCXi%2biic5jqGTgkQlYXsw%3d%3d&crl=c&resultLocal=ErrCrlNoResults&resultNs=Ehost&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d00029270%26AN%3d16103824 en_US
dc.orcid.id https://orcid.org/0000-0002-0120-2275 en_US
dc.author.affiliation Lebanese American University en_US

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