Dexmedetomidine for improved quality of emergence from general anesthesia

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dc.contributor.author Aoud, MT
dc.contributor.author Zeeni, C
dc.contributor.author Al Nawwar, R
dc.contributor.author Siddik-Sayyid, SM
dc.contributor.author Barakat, HB
dc.contributor.author Yazbeck Karam, VG
dc.date.accessioned 2019-05-30T06:46:48Z
dc.date.available 2019-05-30T06:46:48Z
dc.date.copyright 2017 en_US
dc.date.issued 2019-05-30
dc.identifier.issn 1526-7598 en_US
dc.identifier.uri http://hdl.handle.net/10725/10699
dc.description.abstract Dexmedetomidine provides smooth and hemodynamically stable emergence at the expense of hypotension, delayed recovery, and sedation. We investigated the optimal dose of dexmedetomidine for prevention of cough, agitation, hypertension, tachycardia, and shivering, with minimal side effects.In this prospective, randomized, double-blind trial, 216 adult patients were randomly assigned to dexmedetomidine 1 µg/kg (D 1), 0.5 µg/kg (D 0.5), 0.25 µg/kg (D 0.25), or control (C). During emergence, cough, agitation, hemodynamic parameters, shivering, time to extubation, and sedation scores were recorded.A total of 190 patients were analyzed. The respective incidences for the groups D 1, D 0.5, and D 0.25 versus group C were 48%, 64%, and 64% vs 84% for cough-corrected P < .003 between groups D 1 and C; 33%, 34%, and 33% vs 72% for agitation-corrected P < .003 between group C and each of the study groups; and 4%, 2%, and 7% vs 22% for shivering-corrected P = .03 and corrected P = .009 between groups D 1 and D 0.5 versus group C, respectively. The percent increase from baseline blood pressure on extubation for the 3 treatment groups was significantly lower than group C. Percent increase in heart rate was lower than control in groups D 1 and D 0.5 but not in group D 0.25. Time to extubation and sedation scores were comparable. However, more hypotension was recorded during the emergence phase in the 3 treatment groups versus group C.D 1 at the end of surgery provides the best quality of emergence from general anesthesia including the control of cough, agitation, hypertension, tachycardia, and shivering. D 0.5 also controls emergence phenomena but is less effective in controlling cough. The 3 doses do not delay extubation. However, they cause dose-dependent hypotension. en_US
dc.language.iso en en_US
dc.title Dexmedetomidine for improved quality of emergence from general anesthesia en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle a dose-finding study en_US
dc.author.school SOM en_US
dc.author.idnumber 201706801 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Anesthesia and Analgesia en_US
dc.identifier.doi http://dx.doi.org/10.1213/ANE.0000000000002763 en_US
dc.identifier.ctation Aouad, M. T., Zeeni, C., Al, R. N., Siddik-Sayyid, S. M., Barakat, H. B., Elias, S., & Yazbeck, V. K. (2017). Dexmedetomidine for Improved Quality of Emergence From General Anesthesia: A Dose-Finding Study. Anesthesia and analgesia. en_US
dc.author.email rony.alnawar@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://europepmc.org/abstract/med/29293178 en_US
dc.author.affiliation Lebanese American University en_US

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