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Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects

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Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects

Nemr, Rita; Turki, Amira; Echtay, Akram; Al-Zaben, Ghadeer S.; Daher, Hoda S.; Irani-Hakime, Nora A.; Kelestian, Sose H.; Almawi, Wassim Y.
URI: http://hdl.handle.net/10725/10694
URL: https://www.sciencedirect.com/science/article/pii/S0168822712003671
DOI: https://doi.org/10.1016/j.diabres.2012.09.044
Date: 2019-05-29
Terms of Use: This item is made available under the terms and conditions applicable to " Article ", as set forth at: http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php

Abstract:

We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695–rs4506565–rs7903146–rs12243326–rs7895340–rs11196205–rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people.

Citation:

Nemr, R., Turki, A., Echtay, A., Al-Zaben, G. S., Daher, H. S., Irani-Hakime, N. A., ... & Almawi, W. Y. (2012). Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects. Diabetes research and clinical practice, 98(3), e23-e27.

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