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Influence of common and specific HLA-DRB1/DQB1 haplotypes on genetic susceptibilities of three distinct Arab populations to type 1 diabetes

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Influence of common and specific HLA-DRB1/DQB1 haplotypes on genetic susceptibilities of three distinct Arab populations to type 1 diabetes

Stayoussef, Mouna; Benmansour, Jihen; Al-Jenaidi, Fayza A.; Nemr, Rita; Ali, Muhallab E.; Mahjoub, Touhami; Almawi, Wassim Y.
URI: http://hdl.handle.net/10725/10693
URL: https://cvi.asm.org/content/16/1/136.short
DOI: http://dx.doi.org/10.1128/CVI.00215-08
Date: 2019-05-29
Terms of Use: This item is made available under the terms and conditions applicable to " Article ", as set forth at: http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php

Abstract:

The contribution of HLA DRB-DQB to type 1 diabetes (T1D) in Bahrainis, Lebanese, and Tunisians was investigated. DRB1*030101-DQB1*0201 was a locus that conferred susceptibility in three populations, while DRB1*040101-DQB1*0302 was a locus that conferred susceptibility only in Tunisians and Bahrainis. The DRB1*100101-DQB1*050101 (Bahrainis) and DRB1*150101-DQB1*060101 (Lebanese) loci were largely protective. The contribution of HLA to T1D must be evaluated with regard to ethnic background.

Citation:

Stayoussef, M., Benmansour, J., Al-Jenaidi, F. A., Nemr, R., Ali, M. E., Mahjoub, T., & Almawi, W. Y. (2009). Influence of common and specific HLA-DRB1/DQB1 haplotypes on genetic susceptibilities of three distinct Arab populations to type 1 diabetes. Clin. Vaccine Immunol., 16(1), 136-138.

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