Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs

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dc.contributor.author Nemr, Rita
dc.contributor.author Echtay, Akram
dc.contributor.author Dashti, Eman A.
dc.contributor.author Almawi, Ahmad W.
dc.contributor.author Al-Busaidi, Asya S.
dc.contributor.author Kelestian, Sose H.
dc.contributor.author Irani-Hakime, Noha
dc.contributor.author Almawi, Wassim Y.
dc.date.accessioned 2019-05-29T08:42:24Z
dc.date.available 2019-05-29T08:42:24Z
dc.date.copyright 2012 en_US
dc.date.issued 2019-05-29
dc.identifier.issn 1872-8227 en_US
dc.identifier.uri http://hdl.handle.net/10725/10692
dc.description.abstract Objective Several genome-wide association studies and replication analyses have identified common variation at the insulin-like binding protein 2 (IGF2BP2) gene to be associated with type 2 diabetes (T2DM). The aim of this study was to replicate in a Lebanese Arab population identified associations of IGF2BP2 variants rs4402960 and rs1470579 with T2DM. Methods This case–control study involved 544 T2DM patients and 606 control subjects. Genotyping was done by the allelic exclusion method. Results T allele of rs440960 (P = 6.5 × 10−6) and C allele of rs1470579 (P = 5.3 × 10−4) were significantly associated with T2DM; both SNPs were in strong LD (D′ = 0.83, r2 = 0.58). While both IGF2BP2 SNPs were significantly associated with T2DM under additive and recessive models, only rs4402960 remained significantly associated with T2DM under the dominant model. Taking the common rs4402960/rs1470579 GA haplotype as reference, multivariate analysis confirmed the positive association of TC (P = 0.009; OR, 1.43; 95%CI, 1.09–1.87), and TA (P < 0.001; OR = 5.49; 95%CI = 2.09–14.39) haplotypes with increased T2DM risk. These differences remained significant after applying the Bonferroni correction for multiple testing. Conclusion We validate that IGF2BP2 susceptibility variants rs4402960 and rs1470579 associate with T2DM in Lebanese Arabs. en_US
dc.language.iso en en_US
dc.title Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201004815 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Diabetes Research and Clinical Practice en_US
dc.journal.volume 96 en_US
dc.journal.issue 2 en_US
dc.article.pages 225-229 en_US
dc.identifier.doi https://doi.org/10.1016/j.diabres.2011.12.026 en_US
dc.identifier.ctation Nemr, R., Echtay, A., Dashti, E. A., Almawi, A. W., Al-Busaidi, A. S., Keleshian, S. H., ... & Almawi, W. Y. (2012). Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs. Diabetes research and clinical practice, 96(2), 225-229. en_US
dc.author.email rita.nemr@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S016882271100708X en_US
dc.author.affiliation Lebanese American University en_US

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