Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

LAUR Repository

Show simple item record

dc.contributor.author Richarme, Gilbert
dc.contributor.author Liu, Cailing
dc.contributor.author Mihoub, Mouadh
dc.contributor.author Abdallah, Jad
dc.contributor.author Leger, Thibaut
dc.contributor.author Joly, Nicolas
dc.contributor.author Liebart, Jean-Claude
dc.contributor.author Jurkun, Ula V.
dc.date.accessioned 2019-05-28T10:34:13Z
dc.date.available 2019-05-28T10:34:13Z
dc.date.copyright 2017 en_US
dc.date.issued 2019-05-28
dc.identifier.issn 0036-8075 en_US
dc.identifier.uri http://hdl.handle.net/10725/10677
dc.description.abstract DNA damage induced by reactive carbonyls (mainly methylglyoxal and glyoxal), called DNA glycation, is quantitatively as important as oxidative damage. DNA glycation is associated with increased mutation frequency, DNA strand breaks, and cytotoxicity. However, in contrast to guanine oxidation repair, how glycated DNA is repaired remains undetermined. Here, we found that the parkinsonism-associated protein DJ-1 and its bacterial homologs Hsp31, YhbO, and YajL could repair methylglyoxal- and glyoxal-glycated nucleotides and nucleic acids. DJ-1–depleted cells displayed increased levels of glycated DNA, DNA strand breaks, and phosphorylated p53. Deglycase-deficient bacterial mutants displayed increased levels of glycated DNA and RNA and exhibited strong mutator phenotypes. Thus, DJ-1 and its prokaryotic homologs constitute a major nucleotide repair system that we name guanine glycation repair. en_US
dc.language.iso en en_US
dc.title Guanine glycation repair by DJ-1/Park7 and its bacterial homologs en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 200703820 en_US
dc.author.department Pharmaceutical Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Science en_US
dc.journal.volume 357 en_US
dc.journal.issue 6347 en_US
dc.article.pages 208-211 en_US
dc.identifier.doi https://doi.org/10.1126/science.aag1095 en_US
dc.identifier.ctation Richarme, G., Liu, C., Mihoub, M., Abdallah, J., Leger, T., Joly, N., ... & Dairou, J. (2017). Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. Science, 357(6347), 208-211. en_US
dc.author.email jabdallah@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://science.sciencemag.org/content/357/6347/208/tab-article-info en_US
dc.orcid.id https://orcid.org/0000-0001-5267-4953 en_US
dc.author.affiliation Lebanese American University en_US

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search LAUR

Advanced Search


My Account