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Predictors of inflammatory local recurrence after breast-conserving therapy for breast cancer

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dc.contributor.author Akoum, Riad
dc.contributor.author Abdalla, Eddie K.
dc.contributor.author Saade, Michel
dc.contributor.author Awdeh, Adnan
dc.contributor.author Abi-Aad, Fouad
dc.contributor.author Bejjani, Noha
dc.contributor.author Ghossain, Antoine
dc.contributor.author Brihi, Emile
dc.contributor.author Audi, Akram
dc.date.accessioned 2019-05-22T07:07:39Z
dc.date.available 2019-05-22T07:07:39Z
dc.date.copyright 2015 en_US
dc.identifier.issn 0023-9852 en_US
dc.identifier.uri http://hdl.handle.net/10725/10648
dc.description.abstract Inflammatory local recurrence(ILR) after breast-conserving surgery for noninflammatorybreast cancer (BC) is associated with dismal prognosis. Riskfactors for ILR are not well defined. Methods: Between 2001and 2010, twelve patients at our hospital developed ILR afterbreast-conserving surgery, adjuvant chemotherapy, and radiotherapyfor BC. We compared their clinico-pathological characteristicsto those of 24 patients with noninflammatory localrecurrence (non-ILR), 24 patients with distant metastases,and 48 disease-free controls, matched for age and observationperiod. Results: The median time to ILR was 10 months.In univariate analysis, extent of lymph node involvement(p < 0.05), multifocality (p < 0.05), c-erbB2 overexpression(p < 0.05), and lymphovascular invasion (LVI) (p < 0.001)affected the risk of ILR. Conditional logistic regression analysisshowed a significant association between ILR and combinedLVI and high histopathological grade. The odds ratio(OR) for ILR versus non-ILR was 6.14 (95% confidence interval[CI] 1.48-25.38) and for ILR versus distant metastases itwas 3.05 (95% CI 0.09-97.83) when both LVI and high histopathologicalgrade were present. Patients with family historyof BC were more likely to present with ILR than non-ILR(OR 5.47; 95% CI 1.55-19.31) or distant relapse (OR 5.62;95% CI 0.26-119.95). Conclusions: Pre- and postmenopausalwomen with high-grade BC and LVI are at increasedrisk to develop ILR, especially in the presence of family historyof BC. Identification of risk factors for this lethal form ofrecurrent BC may lead to more effective preventive treatmentstrategies in properly selected patients. en_US
dc.language.iso en en_US
dc.title Predictors of inflammatory local recurrence after breast-conserving therapy for breast cancer en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle matched case-control study en_US
dc.author.school SOM en_US
dc.author.idnumber 201000164 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Lebanese Medical Journal en_US
dc.journal.volume 103 en_US
dc.journal.issue 2501 en_US
dc.article.pages 1-8 en_US
dc.identifier.ctation Akoum, R., Abdalla, E. K., Saade, M., Awdeh, A., Abi-Aad, F., Bejjani, N., ... & Audi, A. (2015). Predictors of Inflammatory Local Recurrence after Breast-Conserving Therapy for Breast Cancer: Matched Case-Control Study. Lebanese Medical Journal, 103(2501), 1-8. en_US
dc.author.email adnan.awdeh@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://platform.almanhal.com/GoogleScholar/Details/?ID=2-74352 en_US
dc.author.affiliation Lebanese American University en_US


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