Potential role of temocillin in the treatment of biliary sepsis

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dc.contributor.author Uwaydah, Marwan
dc.contributor.author Vartivarian, Shahe
dc.contributor.author Harakeh, Hani
dc.contributor.author Awdeh, Adnan
dc.contributor.author Najjar, Faysal
dc.date.accessioned 2019-05-22T06:39:13Z
dc.date.available 2019-05-22T06:39:13Z
dc.date.copyright 1985 en_US
dc.date.issued 2019-05-22
dc.identifier.issn 1179-1950 en_US
dc.identifier.uri http://hdl.handle.net/10725/10647
dc.description.abstract Temocillin concentrations were determined in the gallbladder bile and/or common bile duct bile obtained intraoperatively from 20 patients, and in the T-tube bile of 5 postoperative patients. Blood samples were also obtained for determining the concomitant serum antibiotic concentrations. In 6 patients with cholelithiasis, but without common bile duct obstruction or acute infection, the mean temocillin concentrations were 890 mg/L in gallbladder bile and 1030 mg/L in common bile duct bile. In the group of 6 patients with common bile duct obstruction, the antibiotic concentrations ranged between 5.6 and 88 mg/L (mean 38.8 mg/L) in gallbladder bile and between ‘undetectable’ and 700 mg/L in common bile duct bile. In patients with biliary sepsis, a further reduction in temocillin bile concentrations was observed, and postoperatively, the T-tube bile temocillin concentrations were in the range of 21 to 460 mg/L (mean 130 mg/L). The clinical efficacy of temocillin in the 7 patients with acute cholecystitis was judged to be satisfactory. Our results suggest that temocillin may be considered as a potentially useful antibiotic in the treatment of patients with biliary tract sepsis caused by susceptible organisms. en_US
dc.language.iso en en_US
dc.title Potential role of temocillin in the treatment of biliary sepsis en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201000164 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Drugs en_US
dc.journal.volume 29 Supplement 5 en_US
dc.article.pages 186-190 en_US
dc.keywords Commonb bile duct en_US
dc.keywords Acute cholecystitis en_US
dc.keywords Temocillin en_US
dc.keywords Biliary tract disease en_US
dc.keywords Gallbladder bile en_US
dc.identifier.ctation Uwaydah, M., Vartivarian, S., Harakeh, H., Awdeh, A., & Najjar, F. (1985). Potential Role of Temocillin in the Treatment of Biliary Sepsis. Drugs, 29(5), 186-190. en_US
dc.author.email adnan.awdeh@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/article/10.2165/00003495-198500295-00040 en_US
dc.author.affiliation Lebanese American University en_US

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