Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion

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dc.contributor.author Abdalla, Eddie K.
dc.contributor.author Pawlik, Timothy M.
dc.contributor.author Poon, Ronnie T.
dc.contributor.author Ikai, Iwao
dc.contributor.author Nagorney, David M.
dc.contributor.author Belghiti, Jacques
dc.date.accessioned 2019-05-09T06:56:47Z
dc.date.available 2019-05-09T06:56:47Z
dc.date.copyright 2005 en_US
dc.date.issued 2019-05-09
dc.identifier.issn 1532-7361 en_US
dc.identifier.uri http://hdl.handle.net/10725/10598
dc.description.abstract Background The role of hepatic resection in patients with hepatocellular carcinoma (HCC) and invasion of a main portal or hepatic vein branch is controversial. We evaluated the efficacy of hepatic resection and the factors affecting survival after resection in such patients. Methods The records of 102 patients who underwent resection for HCC with major vascular invasion between 1984 and 1999 were reviewed. Prognostic factors were evaluated by univariate and multivariate analysis. Results The study included 87 men and 15 women. The median age was 59 years. The perioperative mortality rate was 5.9%. Median survival was 11 months (median follow-up, 93 months). The 1-, 3-, and 5-year survival rates were 45%, 17%, and 10%; the longest-living survivor was still alive at 14.8 years. Absence of moderate to severe fibrosis and absence of high nuclear grade were associated with a better 5-year survival rate (23% vs 5%; P = .001 and 21% vs 9%; P = .04, respectively). On multivariate analysis, moderate to severe fibrosis remained a significant predictor of both short-term (≤ 6 months) and long-term (>6 months) survival (P < .03 and P < .01, respectively). Conclusions Hepatic resection for HCC with major vascular invasion is associated with median survival exceeding historical survival in patients not treated surgically. Patients with HCC and major vascular invasion who derive long-term benefit from resection have no or minimal underlying fibrosis. en_US
dc.language.iso en en_US
dc.title Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle results of a multicenter study en_US
dc.author.school SOM en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Surgery en_US
dc.journal.volume 137 en_US
dc.journal.issue 4 en_US
dc.article.pages 403-410 en_US
dc.identifier.doi https://doi.org/10.1016/j.surg.2004.12.012 en_US
dc.identifier.ctation Pawlik, T. M., Poon, R. T., Abdalla, E. K., Ikai, I., Nagorney, D. M., Belghiti, J., ... & Lauwers, G. Y. (2005). Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: results of a multicenter study. Surgery, 137(4), 403-410. en_US
dc.author.email eddie.abdalla@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S0039606004007652?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S0039606004007652?via%3Dihub en_US
dc.orcid.id 201100945 en_US
dc.author.affiliation Lebanese American University en_US

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