A new concept to achieve optimal weight gain in malnourished infants on total parenteral nutrition

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dc.contributor.author Abi Nader, Elie
dc.contributor.author Lambe, Cecile
dc.contributor.author Talbotec, Cecile
dc.contributor.author Dong, Liping
dc.contributor.author Pigneur, Benedicte
dc.contributor.author Goulet, Olivier
dc.date.accessioned 2019-05-03T12:57:52Z
dc.date.available 2019-05-03T12:57:52Z
dc.date.copyright 2017 en_US
dc.date.issued 2019-05-03
dc.identifier.issn 1941-2444 en_US
dc.identifier.uri http://hdl.handle.net/10725/10530
dc.description.abstract Background Infants with intestinal failure (IF) are at increased risk of malnutrition and require adapted nutrition support. Optimal weight gain during nutrition rehabilitation should occur at the velocity of statural age (adjusted to the 50th percentile of height) and not chronological age. The aim of this study was to assess the relationship between weight gain during catch‐up growth, nonprotein energy intake (NPEI) provided by total parenteral nutrition (TPN), and resting energy expenditure (REE) in children with severe malnutrition due to IF. Materials and Methods This retrospective study included all infants with severe malnutrition treated with TPN for IF between January 1, 2010, and December 31, 2013. They all had no or minimal oral intake (<10% REE). The REE was calculated using the Schofield equations. Results Seventeen children were included (11 boys) with a mean age at TPN onset of 5 mo. They were followed for a mean duration of 39 days. On admission, body weight and height were –3.1 ± 0.9 and –3.3 ± 1.3 SD, respectively. The indications for TPN were short bowel syndrome (n = 10), congenital enteropathy (microvillous inclusion disease, n = 6) and chronic intestinal pseudo‐obstruction syndrome (n = 1). After 28 days of nutrition rehabilitation with full NPEI from TPN, the observed weight gain was 110 ± 5% of optimal weight gain for statural age. The mean NPEI from TPN was 104.3 ± 8.0 kcal/kg/d. The mean ratio of NPEI over REE was 2.1 ± 0.2. Conclusion Optimal weight gain was achieved with NPEI from TPN twice the REE in severely malnourished infants with IF. NPEI values were adequate and not excessive for age. en_US
dc.language.iso en en_US
dc.title A new concept to achieve optimal weight gain in malnourished infants on total parenteral nutrition en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201004801 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Parental and Enteral Nutrition en_US
dc.journal.volume 42 en_US
dc.journal.issue 1 en_US
dc.article.pages 78-86 en_US
dc.keywords Malnutrition en_US
dc.keywords Infants en_US
dc.keywords Intestinal failure en_US
dc.keywords Total parenteral nutrition en_US
dc.keywords Nonprotein energy intake en_US
dc.keywords Resting energy expenditure en_US
dc.keywords Weight gain en_US
dc.identifier.doi https://doi.org/10.1002/jpen.1014 en_US
dc.identifier.ctation Abi Nader, E., Lambe, C., Talbotec, C., Dong, L., Pigneur, B., & Goulet, O. (2018). A New Concept to Achieve Optimal Weight Gain in Malnourished Infants on Total Parenteral Nutrition. Journal of Parenteral and Enteral Nutrition, 42(1), 78-86. en_US
dc.author.email elie.abinader@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://onlinelibrary.wiley.com/doi/full/10.1002/jpen.1014 en_US
dc.author.affiliation Lebanese American University en_US

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