Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma

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dc.contributor.author Diab, Khalil
dc.contributor.author Raad, Samih
dc.contributor.author Hanna, Nasser
dc.contributor.author Jalal, Shadia
dc.contributor.author Bendaly, Edmond
dc.contributor.author Zhang, Chen
dc.contributor.author Nuguru, Shashank
dc.contributor.author Oueini, Houssam
dc.date.accessioned 2019-05-02T08:25:19Z
dc.date.available 2019-05-02T08:25:19Z
dc.date.copyright 2018 en_US
dc.identifier.issn 1541-8243 en_US
dc.identifier.uri http://hdl.handle.net/10725/10516
dc.description.abstract OBJECTIVES:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the primary method for the diagnosis and staging of lung cancer. The purpose of this study was to assess the yield of EBUS-TBNA in the subtyping and genotyping of lung adenocarcinoma. METHODS:Sixty-nine patients at Indiana University Hospital and Sidney and Lois Eskenazi Hospital with possible or confirmed lung adenocarcinoma underwent EBUS-TBNA using a 21-gauge Olympus needle without suction. Samples were sent for molecular testing after rapid onsite specimen evaluation. A total of 6 to 10 passes were placed in a cell block. RESULTS:Sixty-nine samples from patients with non-small-cell lung cancer were sent for molecular testing for epidermal growth factor receptor. Results were obtained in all of the patients. Mutations were found in three patients (4.3%). Fifty-eight samples were sent for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (100% yield), 10 of which had mutations (17.2%). Fifty-one samples were sent for proto-oncogene tyrosine-protein kinase ROS testing (1 [7.8%] mutant). Tissue samples were inadequate in three patients (94.1% yield). Sixty-three samples were sent for anaplastic lymphoma receptor tyrosine kinase testing (3 [4.8%] mutant, 6 [9.5%] inadequate, 90.5% yield). CONCLUSIONS:EBUS-TBNA with a 21-gauge needle is appropriate for the analysis of multiple mutations and the genotyping of lung adenocarcinoma. en_US
dc.language.iso en en_US
dc.title Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201900605 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Southern Medical Journal en_US
dc.journal.volume 111 en_US
dc.journal.issue 8 en_US
dc.article.pages 484-488 en_US
dc.identifier.doi http://dx.doi.org/10.14423/SMJ.0000000000000846 en_US
dc.identifier.ctation Raad, S., Hanna, N., Jalal, S., Bendaly, E., Zhang, C., Nuguru, S., ... & Diab, K. (2018). Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Use for Subclassification and Genotyping of Lung Non-Small-Cell Carcinoma. Southern medical journal, 111(8), 484-488. en_US
dc.author.email khalil.diab@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://sma.org/southern-medical-journal/article/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-use-for-subclassification-and-genotyping-of-lung-non-small-cell-carcinoma/ en_US
dc.author.affiliation Lebanese American University en_US

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