The efficacy of transcranial direct current stimulation in patients with medication overuse headaches secondary to chronic migraines (P4.128)

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dc.contributor.author Ahdab, Rechdi
dc.contributor.author Riachi, Naji
dc.contributor.author Mansour, Anthony
dc.contributor.author Salem, Maher
dc.contributor.author Khoury, Christelle
dc.contributor.author Sabbouh, Tony
dc.contributor.author Jabri, Tarek
dc.contributor.author Khazen, Georges
dc.date.accessioned 2019-04-30T11:08:40Z
dc.date.available 2019-04-30T11:08:40Z
dc.date.copyright 2018 en_US
dc.date.issued 2019-04-30
dc.identifier.issn 1526-632X en_US
dc.identifier.uri http://hdl.handle.net/10725/10508
dc.description.abstract Objective: Evaluate the efficacy of transcranial direct current stimulation (tDCS) to treat medication overuse headaches (MOH). Background: Patients with occasional migraines use more abortive medications to treat their headaches. They render their medications less effective and develop daily medication overuse headaches (MOH) notoriously difficult to treat. Alternatives to pharmacological treatment are badly needed. Design/Methods: 16 patients with MOH (age: 20–38, 13 women) were randomly assigned in a crossover design to receive 3 consecutive sessions: sham, cathodal tDCS stimulation (2.0 mA, 20 min) over the visual cortex of the dominant side of the migraine pain (O1/O2), and anodal tDCS stimulation over the left dorsolateral prefrontal cortex (DLPFC). Patients filled a migraine diary to record the intensity of pain (using a visual analogue scale) and the number of analgesic pills taken daily for a period extending from one week before (W−1) to one and two weeks after stimulation (W+1 and W+2). Results: We found a statistically significant reduction in the days of severe migraine attacks as compared to baseline (Sham, W−1) for both the Occipital (W+1: 1.06 vs 1.81 p=0.047; W+2: 0.75 vs 1.375 p=0.045) and DLPFC groups (W+1: 0.812 vs 1.81 p=0.015). The analgesic medication use were significantly reduced in the DLPFC group at W+2 (1.66 vs 2.22, p=0.002). The pain intensity was significantly reduced in the Occipital group (W+1: 2.71 vs 4.29, p=0.02). No serious side effects were observed. The procedure was well tolerated. Conclusions: Our results show that cathodal tDCS over the visual cortex and anodal tDCS over the left DLPFC have a significant analgesic effect in MOH and effectively decrease the number of severe migraine days. There was also a significant decrease in the consumption of analgesic medications in the DLPFC group and in the pain intensity in the Occipital group. Disclosure: Dr. Riachi has nothing to disclose. Dr. Mansour has nothing to disclose. Dr. Salem has nothing to disclose. Dr. Khoury has nothing to disclose. Dr. Sabbouh has nothing to disclose. Dr. Jabri has nothing to disclose. Dr. Khazen has nothing to disclose. Dr. Ahdab has nothing to disclose. en_US
dc.language.iso en en_US
dc.title The efficacy of transcranial direct current stimulation in patients with medication overuse headaches secondary to chronic migraines (P4.128) en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100314 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Neurolgy en_US
dc.journal.volume 90 en_US
dc.journal.issue 15 Supplement en_US
dc.identifier.ctation Riachi, N., Mansour, A., Salem, M., Khoury, C., Sabbouh, T., Jabri, T., ... & Ahdab, R. (2018). The Efficacy of Transcranial Direct Current Stimulation in Patients with Medication Overuse Headaches Secondary to Chronic Migraines (P4. 128). Neurology 90 (15 Supplement) en_US
dc.author.email rechdi.ahdab@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://n.neurology.org/content/90/15_Supplement/P4.128 en_US
dc.author.affiliation Lebanese American University en_US

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