Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant

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dc.contributor.author Diab, Khalil J.
dc.contributor.author Yu, Zhangsheng
dc.contributor.author Wood, Karen L.
dc.contributor.author Shmalo, James A.
dc.contributor.author Sheski, Francis D.
dc.contributor.author Farber, Mark O.
dc.contributor.author Wilkes, David S.
dc.contributor.author Nelson, Robert P.
dc.date.accessioned 2019-04-18T12:54:47Z
dc.date.available 2019-04-18T12:54:47Z
dc.date.copyright 2012 en_US
dc.date.issued 2019-04-18
dc.identifier.issn 1083-8791 en_US
dc.identifier.uri http://hdl.handle.net/10725/10480
dc.description.abstract Nonmyeloablative conditioning before allogeneic hematopoietic cell transplant (HCT) is an alternative to conventional conditioning in older patients and those with comorbidities. It is not known whether the decreased tissue injury associated with nonmyeloablative conditioning lowers the risk of pulmonary complications. The medical records of patients who underwent transplantation were reviewed and all pulmonary complications documented. Sixty-two consecutive patients with hematologic malignancies who underwent minimally intensive HCT (subjects) were compared to 48 consecutive patients who received conventional myeloablative allogeneic peripheral blood HCT (controls) over the same period at Indiana University Hospital. Pulmonary complications were categorized according to the type of complication and the time of onset after transplantation. Median follow-up times were similar between groups (P = .70). The study population (minimal intensity recipients) was older (P < .01), and the incidence of chronic graft-versus-host disease (cGVHD) was higher in subjects than controls (P = .02). Sixty-nine percent of subjects and 73% of controls developed pulmonary complications (P = .70). There was a trend in the minimally conditioned patients towards a lower incidence of pulmonary complications in older patients in the early posttransplantation period and a higher incidence of infectious pneumonias and bronchiolitis obliterans syndrome at later time points. The frequency of pulmonary complications seems to be similar after minimally intensive or myeloablative conditioning and allotransplantation. There was no difference in overall mortality or pulmonary-related mortality between the 2 groups. en_US
dc.language.iso en en_US
dc.title Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201900605 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Biology of Blood and Marrow Transplantation en_US
dc.journal.volume 18 en_US
dc.journal.issue 12 en_US
dc.article.pages 1827-1834 en_US
dc.keywords Hematopoietic cell transplant en_US
dc.keywords Pulmonary complications en_US
dc.keywords Nonmyeloablative conditioning en_US
dc.keywords Bronchiolitis obliterans syndrome en_US
dc.identifier.doi https://doi.org/10.1016/j.bbmt.2012.06.013 en_US
dc.identifier.ctation Diab, K. J., Yu, Z., Wood, K. L., Shmalo, J. A., Sheski, F. D., Farber, M. O., ... & Nelson Jr, R. P. (2012). Comparison of pulmonary complications after nonmyeloablative and conventional allogeneic hematopoietic cell transplant. Biology of Blood and Marrow Transplantation, 18(12), 1827-1834. en_US
dc.author.email khalil.diab@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S1083879112002601 en_US
dc.orcid.id https://orcid.org/0000-0001-9255-7575 en_US
dc.author.affiliation Lebanese American University en_US

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