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Noninvasive assessment of coronary flow reserve in the left anterior descending artery by transthoracic echocardiography before and after stenting

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dc.contributor.author Tarcha, Walid
dc.contributor.author Chammas, Elie
dc.contributor.author Dib, Chadi
dc.contributor.author Rahhal, Maya
dc.contributor.author Helou, Toni
dc.contributor.author Ghanem, Georges
dc.date.accessioned 2019-04-16T07:33:12Z
dc.date.available 2019-04-16T07:33:12Z
dc.date.copyright 2007 en_US
dc.date.issued 2019-04-16
dc.identifier.issn 1540-8175 en_US
dc.identifier.uri http://hdl.handle.net/10725/10450
dc.description.abstract Background: Noninvasive assessment of coronary flow reserve in the left anterior descending artery (LAD) by transthoracic Doppler echocardiography (TTDE) has been already validated as a new method for determining the degree of stenosis over the proximal flow. Objectives: The aim of the study is to determine, by TTDE, the feasibility and the value of the coronary flow reserve (CFR) (defined as the maximal increase in coronary blood flow above its basal pressure for a given perfusion pressure when coronary circulation is maximally dilated) in the mid‐to‐distal LAD before and after percutaneous angioplasty and to demonstrate the early recovery of microvascular tone immediately after stenting. Methods: The study population consisted of 36 patients with significant isolated LAD stenosis (70–90%) identified by coronary angiography. CFR was recorded in the mid‐to‐distal LAD at rest and during hyperemia obtained after adenosine intravenous infusion before and after stenting. Results: Adequate visualization of the LAD was obtained in 25 out of 36 patients (70%). At rest the mean CFR was 1.5132 ± 0.33 (1.1–2.58). However, after stenting the mean CFR was significantly higher: 2.18 ± 0.55 (1.3–3.8), with P <0.01. Conclusions: CFR can be easily determined by TTE in approximately 70% of patients. Noninvasive Doppler echocardiography shows impaired CFR in patients with LAD disease. After stenting CFR is restored, demonstrating early recovery of microvascular tone. These results are comparable to those published in the same conditions. Larger series with a long‐term follow‐up may allow identifying patients at high risk for restenosis after stenting. en_US
dc.language.iso en en_US
dc.title Noninvasive assessment of coronary flow reserve in the left anterior descending artery by transthoracic echocardiography before and after stenting en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201004813 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Echocardiography en_US
dc.journal.volume 24 en_US
dc.journal.issue 8 en_US
dc.article.pages 789-794 en_US
dc.identifier.doi https://doi.org/10.1111/j.1540-8175.2007.00478.x en_US
dc.identifier.ctation Chammas, E., Dib, C., Rahhal, M., Helou, T., Ghanem, G., & Tarcha, W. (2007). Noninvasive assessment of coronary flow reserve in the left anterior descending artery by transthoracic echocardiography before and after stenting. Echocardiography, 24(8), 789-794. en_US
dc.author.email walid.tarcha@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://onlinelibrary.wiley.com/doi/full/10.1111/j.1540-8175.2007.00478.x en_US
dc.author.affiliation Lebanese American University en_US


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