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Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains

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dc.contributor.author Riachi, Naji J.
dc.contributor.author Behmand, Ramin A.
dc.contributor.author Harik, Sami I.
dc.date.accessioned 2019-04-15T09:50:31Z
dc.date.available 2019-04-15T09:50:31Z
dc.date.copyright 1991 en_US
dc.identifier.issn 1872-6240 en_US
dc.identifier.uri http://hdl.handle.net/10725/10433
dc.description.abstract We studied 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in 5 strains of rats by assessing mortality and brain monoamine changes after MPTP injections into the internal carotid artery. We then attempted to correlate the differences among rat strains in their susceptibility to MPTP neurotoxicity in vivo with MPTP oxidation by monoamine oxidase (MAO) of the cerebral cortex, striatum, and brain microvessels in vitro. Despite the fact that the carotid route delivers much higher amounts of MPTP to the ipsilateral cerebrum than can be achieved by systemic injections, no significant dopamine depletion occured in ipsilateral striata of Sprague-Dawley rats (the most resistant strain), but significant reductions of about 40% in striatal dopamine were evident in the more sensitive strains. Decreased striatal dopamine levels in these latter rat strains were associated with increased dopamine turnover. Higher doses of MPTP resulted in acute death. MPTP-induced mortality was not affected, but striatal dopamine depletion was prevented, by MAO inhibition. Differences among rat strains in their susceptibility to MPTP neurotoxicity correlated best with MAO activity in their isolated brain microvessels, but not with MAO activity in their striata or cerebral cortices. These results are consistent with the hypothesis that the rats' resistance to MPTP neurotoxicity is to some extent a property of their unique brain endothelium which has high MAO activity. en_US
dc.language.iso en en_US
dc.title Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200902731 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Brain Research en_US
dc.journal.volume 555 en_US
dc.journal.issue 1 en_US
dc.article.pages 19-24 en_US
dc.keywords Monoamine oxidase en_US
dc.keywords Blood-brain barrier en_US
dc.keywords Brain capillary endothelium en_US
dc.keywords 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine en_US
dc.keywords 1-Methyl-4-phenylpyridinium cation en_US
dc.identifier.doi https://doi.org/10.1016/0006-8993(91)90854-O en_US
dc.identifier.ctation Riachi, N. J., Behmand, R. A., & Harik, S. I. (1991). Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains. Brain research, 555(1), 19-24. en_US
dc.author.email naji.riachi@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/000689939190854O en_US
dc.orcid.id https://orcid.org/0000-0002-8652-9698 en_US
dc.author.affiliation Lebanese American University en_US


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