Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain

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dc.contributor.author Riachi, N.J.
dc.contributor.author LaManna, J.C.
dc.contributor.author Harik, S.I.
dc.date.accessioned 2019-04-15T09:20:32Z
dc.date.available 2019-04-15T09:20:32Z
dc.date.copyright 1989 en_US
dc.date.issued 2019-04-15
dc.identifier.issn 1521-0103 en_US
dc.identifier.uri http://hdl.handle.net/10725/10430
dc.description.abstract We studied blood-to-brain entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+) and butanol in anesthetized rats using the indicator-fractionation method with right atrial bolus injection. Minimal amounts of MPP+, which has low octanol/water partition coefficient, crossed the blood-brain barrier. MPTP and butanol, both of which have high octanol/water partition coefficients, were almost completely extracted by all regions of the brain on the first pass. The main difference between the MPTP and butanol tracers is that butanol rapidly left the brain with an exponential rate constant of 1.24 min-1, whereas MPTP was avidly retained by the brain with a washout rate constant of 0.10 min-1 (mean values for the four brain regions that we studied). Early retention of MPTP by the brain was not due to its rapid metabolism by monoamine oxidase because pargyline pretreatment did not affect this rate constant. However, 30 min after [3H]MPTP injection, brain retention of the 3H tracer was reduced significantly by pargyline treatment, and the ratio of brain MPTP/MPP+ was increased markedly. en_US
dc.language.iso en en_US
dc.title Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200902731 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Pharmacology and Experimental Therapeutics en_US
dc.journal.volume 249 en_US
dc.journal.issue 3 en_US
dc.article.pages 744-748 en_US
dc.identifier.ctation Riachi, N. J., LaMANNA, J. C., & Harik, S. I. (1989). Entry of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine into the rat brain. Journal of Pharmacology and Experimental Therapeutics, 249(3), 744-748. en_US
dc.author.email naji.riachi@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://jpet.aspetjournals.org/content/249/3/744.short en_US
dc.orcid.id https://orcid.org/0000-0002-8652-9698 en_US
dc.author.affiliation Lebanese American University en_US

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